That reframing is the whole thing. The facts I already had.
26 likes 5mo
Topic summary
[2026 update] Composite endpoints and the component doing the work
This is a generated summary. It shows the 9 most-liked posts from a topic of 88, in their original order, with the accepted answer included where one exists. It is a reading aid and it will miss nuance — the full topic is the record.
Fairweather, post #4: Everything in the opening post holds. The case it does not cover is the one I have. What I would check first on Composite endpoints is whether the thing being measured moved or whether the way of measuring it moved. Those look identical in a graph. Go to post
Absolute numbers, not just relative: a 30% relative reduction tells you the ratio but not the practical magnitude. The event rate in each arm and the difference between them tells you how many people benefit.
It is one reading of the data and not the only reasonable one.
A request rather than an answer: could whoever has the primary source for Composite endpoints post it? I have seen the claim three times this month and each version had lost a qualifier.
31 likes 5mo
t.kulkarni, post #10: Where I part company with post #9, and it is a narrow parting. Adding what did not work for me on Composite endpoints, since the failures never get written up and they are half the useful information. Go to post
On post #18 — agreed on the reasoning, with one qualification.
Absolute numbers, not just relative: a 30% relative reduction tells you the ratio but not the practical magnitude. The event rate in each arm and the difference between them tells you how many people benefit.
Where I part company with post #45, and it is a narrow parting.
Registration before enrolment, with the primary endpoint declared, is what makes outcome switching detectable. Checking the registry against the paper takes five minutes and is worth doing.
One case, stated as one case.
31 likes 4mo
r.jhannsdttir, post #19: A treatment-policy estimand asks what happens to people assigned to a strategy, including those who abandon it. A hypothetical estimand asks what would have happened had everyone continued. Both are legitimate and they give different numbers. Go to post
Absolute numbers, not just relative: a 30% relative reduction tells you the ratio but not the practical magnitude. The event rate in each arm and the difference between them tells you how many people benefit.
Filing this under things that are true until someone shows me otherwise.
DOdendaal, post #55: Useful. I have added it to my own notes with the date on it. Go to post
Adding the measurement that post #59 says would settle it.
I would call the community position on Composite endpoints likely rather than established, and I would be comfortable defending that hedge.
Post #77 put the caveat in the right place and I want to underline it.
Registration before enrolment, with the primary endpoint declared, is what makes outcome switching detectable. Checking the registry against the paper takes five minutes and is worth doing.
27 likes 3mo
Read the full topic (88 posts)
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- [2026 update] Reading a supplementary appendix and finding the interesting partEvidence › Trials · 44 replies
Promoted into the documentation commons. The content of this topic is maintained at SOUL — trial digest, with named maintainers and a review date. The promotion was discussed in doc review. Corrections are best raised against the document, which is the version that gets kept current.
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