On the subject in the title: Adjudicated events and why the definition matters Working notes rather than a conclusion.
A follow-up question about adjudicated events that I did not know to ask the first time.
The earlier thread answered what I asked. What I should have asked is below, and I think it is the one that matters.
Multiplicity and multiple comparisons: if a trial tests many hypotheses, the chance of a false positive on at least one by random chance increases. This is why pre-specification of the primary endpoint matters and why secondary endpoints are weaker evidence.
Someone will know this better than I do and I hope they say so.
Taking post #2 at face value and following it one step further.
Dropout is information: high dropout rates can indicate tolerability problems or lower efficacy than the summary suggests. Where the analysis handled dropouts matters. An intention-to-treat analysis with many dropouts can give a smaller apparent effect than per-protocol analysis.
I would want a second opinion before relying on that.
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