Oral semaglutide's bioavailability is low and variable, which is why the dose numbers are an order of magnitude different from the injectable. That is a formulation consequence and not a difference in potency. The confident version of this sentence would be wrong, so here is the hedged one.
On the subject in the title: Food effects on oral incretin absorption: what is documented Working notes rather than a conclusion.
Food effects on oral incretin, from the point of view of someone who has read the documentation and is still stuck.
Saying which parts I have understood so that nobody wastes time re-explaining them, and where exactly the understanding stops.
The opening post and I disagree about the size of the effect, not about the direction.
Why administration conditions matter for oral semaglutide and not for injectables: the oral formulation depends on a transient pH effect in the stomach. Anything that changes gastric pH or transit time changes absorption. Food does both.
Oral semaglutide's bioavailability is low and variable, which is why the dose numbers are an order of magnitude different from the injectable. That is a formulation consequence and not a difference in potency.
The confident version of this sentence would be wrong, so here is the hedged one.
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