Practice · Dosing & titration

Titrating on tolerability rather than on the calendar — the long version

Practice › Dosing & titration worked example missed dose titration tirzepatide semaglutide dose reduction

m.dumitruTL213 Oct 2024#1

Titrating on tolerability rather than on the calendar — the long version Writing it up because I had to work it out twice and would rather nobody else did.

A narrow question about Titrating on tolerability, deliberately narrow, because the broad version has been asked here four times and produced four long threads and no answer.

One question, stated units, stated method, and what I have already ruled out.

10 likes 21mo

o.abrahamsenTL3Regular6 Jan 2025#2

Titrating on tolerability rather than on the calendar: some people escalate when they tolerate a dose well, others escalate on the prescribed schedule regardless. The published trials used a calendar-based schedule. Tolerability-based escalation has no formal evidence base but is not uncommon in practice.

I would put this at better than even and not much better.

0 likes 19mo

r.molnarTL27 Mar 2025#3

o.abrahamsen, post #2: Titrating on tolerability rather than on the calendar: some people escalate when they tolerate a dose well, others escalate on the prescribed schedule regardless. The published trials used a calendar-based schedule. Tolerability-based escalation has no formal evidence base but is not uncommon in practice. I would put this at better than… Go to post

Grateful for the specificity. Vague answers to this question are what sent me looking.

29 likes in reply to #2 17mo

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