Compounds · Secretagogues & GH axis · continued

Why pulsatile secretion matters for interpreting secretagogue claims — a second dataset posts 61–65

Compounds › Secretagogues & GH axis GHRP class ipamorelin tesamorelin Under review

This is a continuation of a long topic, addressed by post number rather than by page. Start at post 1.

ew.kuuselaTL223 Apr 2025#61

j.castellanos, post #57: Why this subcategory is stricter about sourcing than most: the evidence base is weaker and that is precisely why documentation quality matters more. A supplier page that clearly identifies the compound and the purity is more valuable for secretagogues than for incretin agonists where the evidence base is stronger. Go to post

Post #59 describes the usual case. This is about the unusual one.

What a well-designed human trial of a secretagogue would look like: randomised, placebo-controlled, adequate sample size, IGF-1 as primary outcome, muscle and strength as secondary outcomes, adequate follow-up duration. Very few secretagogue trials meet that description.

22 likes in reply to #57 15mo

BuchholzTL2Member27 Apr 2025#62

f.danquah, post #44: A mass result for a short peptide is more discriminating than for a long one, because a single residue difference is a larger proportion of the total. That makes identity confirmation genuinely useful here. Take it as a starting point and not as a specification. Go to post

Pulsatile secretion: I have looked for the primary source twice and failed twice. Either it does not exist or it is somewhere I do not know to look, and I would like to know which.

10 likes in reply to #44 15mo

g.danquahTL230 Apr 2025#63

Posting my pulsatile secretion numbers with the method attached so they can be discounted properly. Uncontrolled, unblinded, and collected by someone who wanted a particular answer.

1 like 15mo

s.stavrianosTL24 May 2025#64

Collapsed as off-topic by two members at trust level 3 or above

Confirming post #63 from a second method, which matters more than confirming it from a second person.

Injection-site reactions are reported more often in this family than for the incretins. Whether that is the compounds or the preparations they are typically supplied in is not established.

s.perrinTL28 May 2025#65

v.salgado, post #54: Pulsatile secretion is well covered in the tag pages, and the older discussions are better than the recent ones because they were argued out properly. Worth twenty minutes before adding to this one. Go to post

Answering the question post #63 raises rather than the one it answers.

What I want from this pulsatile secretion thread is the list of things that would need to be true for the claim to hold. If we can write that list, we can check it.

16 likes in reply to #54 15mo

This topic was referenced in

Follow-up: Evidence quality in the secretagogue literature: an honest assessmentCompounds › Secretagogues & GH axis · 24 replies
Coming back to: GHRH analogues versus ghrelin mimetics: different mechanisms, conflated discussionCompounds › Secretagogues & GH axis · 13 replies

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