Topic summary

[2026 update] Evidence quality in the secretagogue literature: an honest assessment

Compounds › Secretagogues & GH axis CJC-1295 GHRP class tesamorelin Closed

This is a generated summary. It shows the 5 most-liked posts from a topic of 19, in their original order, with the accepted answer included where one exists. It is a reading aid and it will miss nuance — the full topic is the record.

h.koodziejTL2Member23 Dec 2025#3

s.demir, post #1: Posting this under the heading it deserves: Evidence quality in the secretagogue literature: an honest assessment Everything below is what sits behind that. I have spent a fortnight trying to pin Evidence quality down and I want to set out where I have got to, because I suspect the honest answer is duller than the thread this will… Go to post

Adding the measurement that the opening post says would settle it.

The documentation on Evidence quality is better than this thread and I say that as someone who has posted in the thread.

24 likes in reply to #1 7mo

v.salgadoTL25 Jan 2026#7

Picking up post #4: that is the part I would want checked first.

My understanding of Evidence quality is a few years old and may have been superseded. If it has been, I would genuinely like to know rather than keep repeating it.

17 likes in reply to #1 7mo

lu.cabreraTL28 Jan 2026#8

On post #7 — agreed on the reasoning, with one qualification.

Growth hormone secretagogues act on the ghrelin receptor or on the growth hormone releasing hormone receptor rather than supplying growth hormone, which is the distinction that matters for anyone reading the literature.

That is my reading. Someone else read the same page differently and was reasonable.

33 likes 7mo

l.krastevTL223 Jan 2026#14

l.ferreira, post #4: Effects reported at the level of appetite are the most consistently described and the most mechanistically direct for the ghrelin-receptor compounds, which is not what most people are taking them for. Second-hand, so weight it accordingly. Go to post

Tesamorelin has an approved indication in HIV-associated lipodystrophy. That is the only compound in this class with a registration-quality evidence base from a proper trial programme. Generalising from that narrow population to healthy adults is a substantial extrapolation.

I would rather be precise about what I do not know than vague about what I do.

32 likes in reply to #4 6mo

a.villalobosTL21 Feb 2026#18

Before the thread moves on from Evidence quality — what is the sample size behind the claim? I am not being difficult; I have seen the same figure quoted from an n of four and from an n of four hundred.

24 likes 6mo

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