Compounds · Secretagogues & GH axis

Evidence quality in the secretagogue literature: an honest assessment

Compounds › Secretagogues & GH axis ipamorelin observational data GHRP class tesamorelin needs a source CJC-1295

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Solved by sa.vogel in post #2

This follows the opening post rather than contradicting it. The pulsatile character of endogenous growth hormone release is why a secretagogue and exogenous growth hormone are not interchangeable, and why a single measured level tells you very little about either. Not the whole picture, but the part of it I can speak…

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s.salgadoTL22 Jul 2026#1

Evidence quality in the secretagogue literature: an honest assessment Writing it up because I had to work it out twice and would rather nobody else did.

I have spent a fortnight trying to pin evidence quality down and I want to set out where I have got to, because I suspect the honest answer is duller than the thread this will produce.

What I have: a consistent observation across a small number of cases, collected the same way each time. What I do not have: any controlled comparison, or any reason to think my cases are representative.

The specific question is whether the pattern survives once the obvious confounder is removed. I cannot remove it with what I have.

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sa.vogelTL2 Solution12 Jul 2026 · edited#2

This follows the opening post rather than contradicting it.

The pulsatile character of endogenous growth hormone release is why a secretagogue and exogenous growth hormone are not interchangeable, and why a single measured level tells you very little about either.

Not the whole picture, but the part of it I can speak to.

10 likes 16d

KTurkingtonTL3Regular19 Jul 2026#3

Right — I had this wrong and I am glad to have read it before it mattered.

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This topic was referenced in

About the Secretagogues & GH axis categoryCompounds › Secretagogues & GH axis · 10 replies
Ipamorelin selectivity claims and where they came fromCompounds › Secretagogues & GH axis · 56 replies

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