I had written a reply contradicting the opening post and deleted it. Here is what survived.
Widely repeated interaction claim would be much easier to settle if anyone reported the denominator. Almost nobody reports the denominator.
Topic summary
A widely repeated interaction claim that turns out to be unsupported — what changed since
This is a generated summary. It shows the 9 most-liked posts from a topic of 95, in their original order, with the accepted answer included where one exists. It is a reading aid and it will miss nuance — the full topic is the record.
Where a published interaction study exists it usually reports an area-under-curve ratio, and that number is far more informative than a yes-or-no answer.
I would treat that as a working assumption and revisit it.
29 likes 4mo
pe.onwuka, post #21: The most defensible general position in this subcategory: identify the plausible mechanism, check whether it has been studied, and where it has not, say that rather than filling the gap. A weak preference rather than a position. Go to post
Supplements and herbs: many have no established interaction. Some do. If you are taking something unusual, checking a reference (like a pharmacist) is more useful than guessing from forum discussion.
Noting that I have skin in this question and have tried to discount for it.
Absence of an interaction study is not evidence of no interaction. A great many combinations discussed here have simply never been studied, and saying so is more useful than reasoning from mechanism alone.
30 likes 3mo
a.krastev, post #4: Anything that also slows gut motility compounds the same mechanism. That is a plausibility argument rather than a documented interaction, and it should be labelled as one. Go to post
I had written a reply contradicting post #30 and deleted it. Here is what survived.
Gastrointestinal symptoms from one compound can mask or mimic an interaction with another. Introducing two changes at once makes attribution impossible, which is an argument for spacing them.
a.nascimento, post #2: Marking my place. If it changes for me I will come back and say so. Go to post
Vitamins: most vitamins have no significant interaction. Fat-soluble vitamins (A, D, E, K) might be affected by the slowing of fat absorption during weight loss, but that is a nutritional consequence rather than an interaction.
That is what the documentation says. What happens in practice is usually close.
j.lokken, post #48: Building on post #47 rather than restating it. Nothing here is medical advice and an interaction question is one where the cost of a wrong forum answer is genuinely high. Ask the prescriber or the pharmacist. Go to post
Post #56 put the caveat in the right place and I want to underline it.
Offering a way to settle widely repeated interaction claim rather than another opinion about it. Two measurements, taken the same way, a fortnight apart. If the difference is within the noise, the question was not answerable at this precision.
Post #79 is the version of this I will quote in future. One addition.
A pharmacist can answer most questions in this subcategory in a few minutes with access to a proper interaction database, and that access is the thing a forum does not have.
Reading it again, the caveat matters more than the finding.
32 likes 18d
Read the full topic (95 posts)
This topic was referenced in
- Delayed gastric emptying and oral medication absorption: which drugs matterPractice › Interactions · 116 replies
- Second pass at: Metformin co-administration and additive GI effectsPractice › Interactions · 142 replies
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