Topic summary

Angle of injection and whether 90 degrees is always right

Practice › Administration aseptic technique missed dose injection site reaction

This is a generated summary. It shows the 9 most-liked posts from a topic of 117, in their original order, with the accepted answer included where one exists. It is a reading aid and it will miss nuance — the full topic is the record.

d.barrosTL221 Jul 2025 · edited#3

c.castellanos, post #2: I had written a reply contradicting the opening post and deleted it. Here is what survived. Leak-back after withdrawal: a small amount of liquid on the skin after withdrawal is ordinary. Whether you lost a "meaningful" dose depends on concentration and your target dose, but some leak-back is universal and does not need to be treated as… Go to post

If you have to inject at a different time of day than usual, that is a much smaller perturbation than it feels for a weekly compound with a week-long half-life.

Old habit: I write down the expected answer before I calculate it.

26 likes in reply to #2 12mo

n.haddadTL211 Oct 2025#34

Post #33 is right about the mechanism and I think understates the practical bit.

If you have to inject at a different time of day than usual, that is a much smaller perturbation than it feels for a weekly compound with a week-long half-life.

I am not the right person to answer the follow-up to this.

31 likes 10mo

m.balogunTL214 Nov 2025#50

e.roos, post #10: On angle of injection I would separate what is worth knowing from what is worth acting on. The first list is long and the second is short, and conflating them is how threads get heated. Go to post

Reframing angle of injection slightly, because I think the disagreement is about the question rather than the answer. If the question is "does it happen", yes. If it is "how often", nobody here knows.

29 likes in reply to #10 8mo

g.valckenaereTL3Regular17 Dec 2025#67

Adding a data point of agreement rather than a data point.

31 likes 7mo

FFaulknerTL3Regular5 Jan 2026#77

Worth separating two things that post #74 runs together.

Second-hand on angle of injection, so weight it accordingly — someone whose method I trust told me this and I have not verified it myself.

29 likes 7mo

microgramsTL2Regular17 Jan 2026#84

A new needle for each injection is not fussiness. A needle blunts on first use and a blunted needle is the reason the second injection hurts more than the first.

The mechanism is plausible, which is not the same as established.

29 likes 6mo

a.kwiatkowskiTL2Member7 Feb 2026#96

Right, and stated more narrowly than I would have dared to state it.

27 likes 6mo

b.wikstromTL23 Mar 2026#110

m.balogun, post #50: Reframing angle of injection slightly, because I think the disagreement is about the question rather than the answer. If the question is "does it happen", yes. If it is "how often", nobody here knows. Go to post

Drawing up with one needle and injecting with another: a reasonable practice if you have extra needles. Fresh needle for injection reduces tissue drag and can decrease discomfort. Not necessary, but not harmful either.

32 likes in reply to #50 5mo

q.zhao_qaTL3Quality assurance7 Mar 2026#112

Answering the question post #108 raises rather than the one it answers.

The arithmetic on angle of injection is the easy part and it is where the errors are, which is an uncomfortable combination. Show your working and someone will catch it.

28 likes 5mo

Read the full topic (117 posts)

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