Coming back to post #3, because the follow-up matters more than the original answer.
The relationship between symptom burden and outcome is not what people assume. Feeling worse is not evidence of a larger effect and feeling nothing is not evidence of an inactive preparation.
Grateful for the specificity. Vague answers to this question are what sent me looking.
The thing about Constipation management that took me longest to accept is that a plausible mechanism is not evidence of an effect. It is a reason to look, not a result.
What would change my mind on Constipation management is a second dataset collected by someone with no stake in the first. Until then I hold it loosely and I would rather say so than pretend to more.
Constipation management would be much easier to settle if anyone reported the denominator. Almost nobody reports the denominator.
Read the full topic (36 posts)
| Topic | Participants | Replies | Views | Activity |
|---|---|---|---|---|
|
Sulphur-smelling eructation: mechanism and what helps
Sulphur-smelling eructation: mechanism and what helps — setting out what I have, and where I think it stops being reliable. I would like to disagree carefully with the settled view on sulphur-smelling…
|
2 | 58 | 1d | |
|
Distinguishing expected GI effects from something that needs urgent attention
Distinguishing expected GI effects from something that needs urgent attention Writing it up because I had to work it out twice and would rather nobody else did. Reporting something rather than asking about…
|
+88 | 101 | 32k | 6mo |
|
Dizziness on standing and the electrolyte explanation — does this still hold?
The question in the title: Dizziness on standing and the electrolyte explanation — does this still hold? I will give what I have already checked below so nobody repeats it. Trying to work out what would count…
|
+89 | 94 | 18k | 1mo |
|
Vomiting: when it is expected and when it is a reason to stop — one year on
Vomiting: when it is expected and when it is a reason to stop — one year on Writing it up because I had to work it out twice and would rather nobody else did. Reporting something rather than asking about it,…
|
+19 | 23 | 49k | 18h |
|
About the Side effects category
Recognition, grading, timeline, and management. Adverse events that need urgent attention belong in Safety. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is…
|
4 | 7.1k | 13mo |
| Topic | Participants | Replies | Views | Activity |
|---|---|---|---|---|
|
The headache that turns out to be dehydration — the long version
On the subject in the title: The headache that turns out to be dehydration — the long version Working notes rather than a conclusion. A narrow question about headache, deliberately narrow, because the broad…
|
+68 | 73 | 1.3k | 12h |
|
Revisiting: Taste changes and food aversion, reported and discussed
Revisiting: Taste changes and food aversion, reported and discussed Writing it up because I had to work it out twice and would rather nobody else did. Two things I would like separated before anyone answers…
|
+20 | 25 | 4.3k | 1d |
|
Whether protein timing matters at a large deficit
Posting this under the heading it deserves: Whether protein timing matters at a large deficit Everything below is what sits behind that. A follow-up question about whether protein timing that I did not know…
|
+29 | 33 | 7.7k | 4mo |
|
Sleep quality changes during weight loss — what changed since
Sleep quality changes during weight loss — what changed since Writing it up because I had to work it out twice and would rather nobody else did. What changes if the standard account of Sleep quality changes…
|
+68 | 74 | 10k | 8mo |
|
The nausea timeline across the first four weeks, with a tabulated log — what changed since
On the subject in the title: The nausea timeline across the first four weeks, with a tabulated log — what changed since Working notes rather than a conclusion. What changes if the standard account of nausea…
|
+24 | 29 | 2.8k | 6mo |