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Practice · Side effects

Follow-up: Constipation management, with a dietitian's contribution

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k.agyemanTL27 Oct 2025#1

Constipation management, with a dietitian's contribution — setting out what I have, and where I think it stops being reliable.

A follow-up question about Constipation management that I did not know to ask the first time.

The earlier thread answered what I asked. What I should have asked is below, and I think it is the one that matters.

0 likes 10mo
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BramleyTL2Member10 Oct 2025#2

Thank you for taking the time. That was more work than a reply usually is.

21 likes 10mo
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r.chukwuTL212 Oct 2025#3

Reading this Constipation management thread as someone who came in with a fixed view: the third and seventh replies moved me and the confident ones did not.

9 likes 9mo
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cohort_driftTL3Regular15 Oct 2025 · edited#4
r.chukwu, post #3: Reading this Constipation management thread as someone who came in with a fixed view: the third and seventh replies moved me and the confident ones did not. Go to post

Picking up post #3: that is the part I would want checked first.

The number people quote for Constipation management is a central estimate presented without its interval, and the interval is wide enough that the estimate is nearly uninformative on its own.

2 likes in reply to #3 9mo
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n.vogelTL216 Oct 2025#5

Coming back to post #3, because the follow-up matters more than the original answer.

The relationship between symptom burden and outcome is not what people assume. Feeling worse is not evidence of a larger effect and feeling nothing is not evidence of an inactive preparation.

30 likes 9mo
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o.cousineauTL3Regular18 Oct 2025#6

The published rates come from populations that were titrated on a defined schedule with clinical supervision. Rates from a forum are not comparable and are biased by who chooses to post.

I would be glad to be shown a cleaner way of putting this.

15 likes 9mo
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n.nakamuraTL220 Oct 2025#7

One caution on Constipation management: everything above assumes the underlying documentation is what it claims to be. That assumption is doing real work and is rarely stated.

6 likes 9mo
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c.niemelTL322 Oct 2025#8
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f.wojcikTL223 Oct 2025#9
c.niemel, post #8: The version of Constipation management that I was taught turned out to be a teaching simplification. Useful, and not true in the way I had assumed it was. Go to post

Grateful for the specificity. Vague answers to this question are what sent me looking.

22 likes in reply to #8 9mo
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s.rasmussenTL225 Oct 2025#10

Post #7 answers the question as asked. The question underneath it is different.

The relationship between symptom burden and outcome is not what people assume. Feeling worse is not evidence of a larger effect and feeling nothing is not evidence of an inactive preparation.

10 likes 9mo
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s.adebayoTL226 Oct 2025#11

Posting my Constipation management numbers with the method attached so they can be discounted properly. Uncontrolled, unblinded, and collected by someone who wanted a particular answer.

0 likes 9mo
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weekly_pinTL2Regular28 Oct 2025#12

Post #10 and I disagree about the size of the effect, not about the direction.

Constipation management: I have looked for the primary source twice and failed twice. Either it does not exist or it is somewhere I do not know to look, and I would like to know which.

5 likes 9mo
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h.lindqvistTL229 Oct 2025#13

Narrowing post #12, because the general version has more than one answer.

The published rates come from populations that were titrated on a defined schedule with clinical supervision. Rates from a forum are not comparable and are biased by who chooses to post.

I have no interest in any supplier named above.

13 likes 9mo
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appeals_deskTL3Regular31 Oct 2025#14
k.agyeman, post #1: Constipation management, with a dietitian's contribution — setting out what I have, and where I think it stops being reliable. A follow-up question about Constipation management that I did not know to ask the first time. The earlier thread answered what I asked. What I should have asked is below, and I think it is the one that matters. Go to post

The thing about Constipation management that took me longest to accept is that a plausible mechanism is not evidence of an effect. It is a reason to look, not a result.

27 likes in reply to #1 9mo
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j.vogelTL21 Nov 2025#15
o.cousineau, post #6: The published rates come from populations that were titrated on a defined schedule with clinical supervision. Rates from a forum are not comparable and are biased by who chooses to post. I would be glad to be shown a cleaner way of putting this. Go to post

Building on post #12 rather than restating it.

Recognition and grading: nausea ranges from "noticeable" to "limiting". Constipation ranges from mild to severe. Having language to describe the magnitude helps you track whether something is worsening or stable and helps your clinician understand what you are reporting.

That is the version I would defend. It is not the version I started with.

0 likes in reply to #6 9mo
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TL4_HalvorsenTL4Leader · Journal club2 Nov 2025#16

Useful. I have added it to my own notes with the date on it.

2 likes 9mo
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t.dumitruTL24 Nov 2025#17

The relationship between symptom burden and outcome is not what people assume. Feeling worse is not evidence of a larger effect and feeling nothing is not evidence of an inactive preparation.

I would treat the number as indicative rather than as a measurement.

9 likes 9mo
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endo_fellow_rkTL3Endocrinology fellow5 Nov 2025 · edited#18
r.chukwu, post #3: Reading this Constipation management thread as someone who came in with a fixed view: the third and seventh replies moved me and the confident ones did not. Go to post

I have been on both sides of the Constipation management argument in this category within eighteen months, which should tell you how strong the evidence for either side is.

20 likes in reply to #3 9mo
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v.stanescuTL26 Nov 2025#19

Post #17 is the version of this I will quote in future. One addition.

Whatever the answer on Constipation management turns out to be, the method for getting there is the same: state the assumption, do the arithmetic in public, invite the correction.

4 likes 9mo
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NicolaidesTL3Regular8 Nov 2025#20

The published rates come from populations that were titrated on a defined schedule with clinical supervision. Rates from a forum are not comparable and are biased by who chooses to post.

Reporting the observation and leaving the explanation open deliberately.

13 likes 9mo
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c.falkTL29 Nov 2025#21

Saving this. It is the version I will quote when the question comes round again.

2 likes 9mo
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septum_entryTL2Member10 Nov 2025#22

Constipation: common, manageable, and frequently under-reported because it is not dramatic. Increasing fibre and fluid intake helps. Over-the-counter management is usually effective. This is worth addressing proactively rather than waiting for it to worsen.

I have said this before in a thread nobody could find, so it is worth repeating.

0 likes 9mo
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f.laurentTL212 Nov 2025#23
t.dumitru, post #17: The relationship between symptom burden and outcome is not what people assume. Feeling worse is not evidence of a larger effect and feeling nothing is not evidence of an inactive preparation. I would treat the number as indicative rather than as a measurement. Go to post

I read post #19 twice before replying, because I had assumed the opposite.

I would rather this thread reach "we do not know" about Constipation management than reach a confident answer that nobody can support when asked.

21 likes in reply to #17 8mo
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LundqvistTL2Member13 Nov 2025#24

The most useful thing anyone has posted about Constipation management in this category was a table of what had been measured and by whom. That is what I would want again.

9 likes 8mo
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h.eriksenTL214 Nov 2025#25
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z.laurentTL215 Nov 2025 · edited#26

Taking post #23 at face value and following it one step further.

The useful distinction on Constipation management is between what was measured and what was inferred from it. Both end up in the same sentence and only one of them has error bars.

0 likes 8mo
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k.chukwuTL216 Nov 2025#27
f.laurent, post #23: I read post #19 twice before replying, because I had assumed the opposite. I would rather this thread reach "we do not know" about Constipation management than reach a confident answer that nobody can support when asked. Go to post

What would change my mind on Constipation management is a second dataset collected by someone with no stake in the first. Until then I hold it loosely and I would rather say so than pretend to more.

28 likes in reply to #23 8mo
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apostille_traceTL1Member18 Nov 2025#28
endo_fellow_rk, post #18: I have been on both sides of the Constipation management argument in this category within eighteen months, which should tell you how strong the evidence for either side is. Go to post

The relationship between symptom burden and outcome is not what people assume. Feeling worse is not evidence of a larger effect and feeling nothing is not evidence of an inactive preparation.

The short version is the first sentence; the rest is why.

14 likes in reply to #18 8mo
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f.villalobosTL219 Nov 2025#29

Post #27 describes the usual case. This is about the unusual one.

Adding a null result on Constipation management. I looked, carefully, and found nothing, and null results deserve posting precisely because they never are.

0 likes 8mo
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t.pereiraTL220 Nov 2025#30
o.cousineau, post #6: The published rates come from populations that were titrated on a defined schedule with clinical supervision. Rates from a forum are not comparable and are biased by who chooses to post. I would be glad to be shown a cleaner way of putting this. Go to post

Constipation management would be much easier to settle if anyone reported the denominator. Almost nobody reports the denominator.

29 likes in reply to #6 8mo