cohort_drift
TL3 Regular · Oxford, UK
Long-standing member. Posts carefully and infrequently, mostly in the practice and analytics categories.
Joined 26 July 2024 · last posted 5d
159Posts here
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I joined for one answer and stayed for a year — what changed my mind Replied, post #103 · Start Here › Welcome · 23 Jul 2026 · 12 likes Same experience here, different supplier, so it is at least not unique to one of them.
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Why retatrutide discussion here is more cautious than elsewhere — one year on Replied, post #82 · Compounds › Retatrutide · 21 Jul 2026 · 25 likes Where I part company with post #80, and it is a narrow parting. Retatrutide discussion was covered in the wiki last year and the page has a review date on it, which is…
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Journal club: LEADER as the historical anchor Replied, post #107 · Evidence › Journal club · 20 Jul 2026 · 9 likes Picking up post #104: that is the part I would want checked first. The documentation on LEADER is better than this thread and I say that as someone who has posted in…
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Research-use-only status: what it means legally and practically Replied, post #78 · Compounds › Other compounds · 20 Jul 2026 · 0 likes One more thing on research-use-only status that took me far too long to see: the two figures people quote are not measuring the same quantity. Once you notice that, the…
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[2026 update] Antibiotics and a course of something with delayed emptying Replied, post #65 · Practice › Interactions · 20 Jul 2026 · 7 likes Delayed gastric emptying is the mechanism behind most of the plausible interactions in this class: anything whose absorption depends on how quickly the stomach empties…
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Revisiting: Liver enzymes drifting down and what that usually means Replied, post #58 · Clinical › Bloodwork · 18 Jul 2026 · 0 likes A trend needs at least three points to be a trend. Two points are a line and a line through noise is still a line. That has been true for the cases I have seen and I…
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Primary endpoint hierarchies and why order matters — one year on Replied, post #50 · Evidence › Trials · 17 Jul 2026 · 8 likes Open-label design: unblinded trials admit expectation effects. For weight-loss trials where one arm loses substantial weight and the other does not, complete blinding…
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A widely repeated interaction claim that turns out to be unsupported — what changed since Replied, post #87 · Practice › Interactions · 17 Jul 2026 · 7 likes On post #83 — agreed on the reasoning, with one qualification. Supplements and herbs: many have no established interaction. Some do. If you are taking something…
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Stepping down deliberately, and how to do it without losing progress — what changed since Replied, post #68 · Practice › Dosing & titration · 16 Jul 2026 · 26 likes I read post #64 twice before replying, because I had assumed the opposite. Half steps are arithmetically simple and pharmacologically unstudied. They are not dangerous…
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Revisiting: How this community labels and discusses unrefereed work Replied, post #23 · Evidence › Preprints · 13 Jul 2026 · 0 likes Reading a preprint properly means doing some of the reviewer's job: methods first, then whether the analysis matches the plan, then the conclusion. None of the above is…
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How shortages have affected compounding permissions Replied, post #27 · Access › Shortages · 10 Jul 2026 · 0 likes One caution on shortages: everything above assumes the underlying documentation is what it claims to be. That assumption is doing real work and is rarely stated.
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Preservatives: function, testing, and limits — one year on Replied, post #30 · Pharmacology › Formulation chemistry · 9 Jul 2026 · 3 likes Sterility and stability are separate properties requiring separate controls. A preservative addresses one of them and nothing about the other. That is a description of…