Levothyroxine timing: a real interaction with a simple fix

Confirming the opening post from a second method, which matters more than confirming it from a second person.

Anything that also slows gut motility compounds the same mechanism. That is a plausibility argument rather than a documented interaction, and it should be labelled as one.

It is the sort of thing that seems obvious in retrospect and was not at the time.

Post #6 is right about the mechanism and I think understates the practical bit.

Renal or hepatic impairment changes the calculus for a lot of combinations and is the context most often missing from an interaction question here.

I looked this up rather than remembered it, which is the right order.

The practical advice most consistently given by pharmacists here is to keep the timing of other oral medication consistent rather than to change it, because consistency is what makes a problem visible.

Anticoagulant questions come up regularly and are the clearest case for professional advice rather than discussion, because the consequence of being wrong is not gradual.

This has been discussed before and I could not find the thread, so, again.

Absence of an interaction study is not evidence of no interaction. A great many combinations discussed here have simply never been studied, and saying so is more useful than reasoning from mechanism alone.

Adding it in case it saves somebody the afternoon it cost me.