Posting this under the heading it deserves: The SOUL trial and oral semaglutide cardiovascular outcomes Everything below is what sits behind that.
Collecting what is known about SOUL trial and oral semaglutide in one place, because it is currently spread across a category, two tag pages and a thread that is hard to find.
This is a summary rather than new work, and I have attributed each part to where I found it.
Oral semaglutide's bioavailability is low and variable, which is why the dose numbers are an order of magnitude different from the injectable. That is a formulation consequence and not a difference in potency.
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Oral versus injectable exposure: comparing apples to a different fruit — a second dataset
Posting this under the heading it deserves: Oral versus injectable exposure: comparing apples to a different fruit — a second dataset Everything below is what sits behind that. Something about Oral versus…
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+27 | 31 | 17k | 25d |
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Dose numbers for oral formulations are not comparable to injectable ones
On the subject in the title: Dose numbers for oral formulations are not comparable to injectable ones Working notes rather than a conclusion. Putting the numbers in the first post, because a question about a…
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+19 | 23 | 39k | 6mo |
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Oral semaglutide bioavailability and its variability between people — a second dataset
Oral semaglutide bioavailability and its variability between people — a second dataset — setting out what I have, and where I think it stops being reliable. Posting a small dataset on Oral semaglutide…
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+141 | 154 | 47k | 19mo |
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Why oral semaglutide needs an absorption enhancer at all — one year on
Why oral semaglutide needs an absorption enhancer at all — one year on — that is the question, and I have not found it answered plainly anywhere I have looked. Reading back through what has been written here…
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+11 | 15 | 17k | 24d |
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SNAC and the mechanism of oral peptide absorption
On the subject in the title: SNAC and the mechanism of oral peptide absorption Working notes rather than a conclusion. A comparison question rather than a question about one compound. Two things in the same…
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+13 | 17 | 14k | 17mo |
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[2026 update] Tirzepatide in obstructive sleep apnoea: reading SURMOUNT-OSA
Tirzepatide in obstructive sleep apnoea: reading SURMOUNT-OSA — setting out what I have, and where I think it stops being reliable. Reading back through what has been written here about Tirzepatide in…
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2 | 58k | 11mo | |
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Why fasting instructions for oral semaglutide are not optional advice — does this still hold?
Asking directly, because I could not find a straight answer: Why fasting instructions for oral semaglutide are not optional advice — does this still hold? A methods question rather than a substantive one,…
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+98 | 106 | 3.1k | 10mo |
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Second pass at: Historical amylin analogues and what happened to them
Second pass at: Historical amylin analogues and what happened to them — setting out what I have, and where I think it stops being reliable. The question about Historical amylin analogues that I actually want…
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+15 | 19 | 22k | 18mo |
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[2026 update] Reading a supplementary appendix and finding the interesting part
On the subject in the title: Reading a supplementary appendix and finding the interesting part Working notes rather than a conclusion. Collecting what is known about Reading a supplementary appendix in one…
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+39 | 44 | 8.2k | 5mo |
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Journal club: what we got wrong in an earlier session
On the subject in the title: Journal club: what we got wrong in an earlier session Working notes rather than a conclusion. Bringing a claim rather than a paper, because the claim is the thing circulating. The…
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+114 | 125 | 2.5k | 23h |