Tirzepatide in obstructive sleep apnoea: reading SURMOUNT-OSA — setting out what I have, and where I think it stops being reliable.
Reading back through what has been written here about Tirzepatide in obstructive sleep apnoea, three questions come up every time and only one has ever been answered properly.
Listing all three, with what I think the state of the answer is for each, so the thread can start further along than the last one did.
Titration schedules for tirzepatide have more dose steps than semaglutide partly because the compound is more potent and partly because the clinical programme used a finer gradation. That does not mean you cannot escalate on a coarser schedule if that suits you — the published schedule is not a lower bound.
Research-use-only tirzepatide is not approved for human use and is not made to pharmaceutical standards. Anyone discussing it here is describing what they did, not recommending it.
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Tirzepatide storage and stability: what is published versus what is assumed
On the subject in the title: Tirzepatide storage and stability: what is published versus what is assumed Working notes rather than a conclusion. Asking about tirzepatide storage and stability directly,…
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+17 | 21 | 17k | 12d |
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Follow-up: Tirzepatide and nausea: is the profile genuinely different or just differently reported?
Tirzepatide and nausea: is the profile genuinely different or just differently reported? I have a specific reason for asking rather than idle curiosity, and the context is below. Something about Tirzepatide…
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+109 | 122 | 3.6k | 2mo |
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Revisiting: Why tirzepatide titration schedules have more steps than semaglutide's
Revisiting: Why tirzepatide titration schedules have more steps than semaglutide's Writing it up because I had to work it out twice and would rather nobody else did. I would like to know what people here…
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+89 | 101 | 32k | 8mo |
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Why tirzepatide titration schedules have more steps than semaglutide's
Asking directly, because I could not find a straight answer: Why tirzepatide titration schedules have more steps than semaglutide's I have spent a fortnight trying to pin tirzepatide titration schedules down…
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4 | 8.4k | 7mo | |
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Tirzepatide's shorter half-life and its one practical consequence
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+18 | 29 | 20k | 8mo |
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Journal club: the CagriSema phase 2 combination paper
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2 | 329 | 21h | |
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Journal club: STEP 3 and the intensive behavioural therapy floor — does this still hold?
The question in the title: Journal club: STEP 3 and the intensive behavioural therapy floor — does this still hold? I will give what I have already checked below so nobody repeats it. Asking about STEP 3 on…
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2 | 15k | 10mo | |
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What I would record differently if I started again — the long version
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+22 | 26 | 57k | 5mo |
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A structured critique template this community uses
A structured critique template this community uses — setting out what I have, and where I think it stops being reliable. Structured critique template — I have the observation and I do not trust my…
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2 | 18k | 1d | |
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Amylin receptor signalling and satiety
Amylin receptor signalling and satiety Writing it up because I had to work it out twice and would rather nobody else did. Asking about amylin receptor signalling and satiety directly, because I have read four…
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+22 | 26 | 1.8k | 9mo |