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Evidence · Preprints · continued

The "under review" status pill and when a moderator applies it posts 31–60

This is a continuation of a long topic, addressed by post number rather than by page. Start at post 1.

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a.mwangiTL221 Mar 2026#31

How to cite a preprint: author last name, first initial, et al. Title. Server name [preprint]. Posted date. Doi. Include the server name and note that it is a preprint.

28 likes 4mo
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cannula_driftTL3Regular22 Mar 2026#32

Media coverage of preprints rarely mentions the status. That is where most of the downstream confusion in this subcategory originates.

I would rather post the uncertainty than round it away.

13 likes 4mo
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b.vestergaardTL223 Mar 2026 · edited#33
d.oyelaran, post #12: The honest position on most preprints in this field is that they are interesting and provisional, and that saying both is not fence-sitting. Two people can read the same figure differently here and both be reasonable. Go to post

Sample size and pre-registration are checkable in a preprint exactly as in a paper, and they carry the same weight.

I would call that likely rather than established.

2 likes in reply to #12 4mo
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BGiordanoTL2Member23 Mar 2026#34
o.vogel, post #4: Unrefereed work is not worthless. A great deal of it survives review substantially unchanged. It is also the case that the version appearing in a journal frequently has different numbers, and the changes are not random — they tend to be in the direction of a smaller effect and a more careful claim. Go to post

Adding the measurement that post #31 says would settle it.

Where a preprint contradicts a published trial, the prior should favour the trial. Where it extends one, the preprint can be genuinely useful.

None of the above is medical advice and I am not qualified to give any.

0 likes in reply to #4 4mo
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b.solbergTL224 Mar 2026#35

This is the answer, and the reason it is the answer is the more useful part.

0 likes 4mo
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m.coelhoTL225 Mar 2026#36
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k.radichTL225 Mar 2026#37

On post #34 — agreed on the reasoning, with one qualification.

Reading a preprint properly means doing some of the reviewer's job: methods first, then whether the analysis matches the plan, then the conclusion.

Adding it because I spent an afternoon working it out and nobody should have to twice.

5 likes 4mo
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h.mbekiTL226 Mar 2026#38
Woodhouse, post #9: Where a preprint contradicts a published trial, the prior should favour the trial. Where it extends one, the preprint can be genuinely useful. Go to post

Picking up post #37: that is the part I would want checked first.

Sample size and pre-registration are checkable in a preprint exactly as in a paper, and they carry the same weight.

0 likes in reply to #9 4mo
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a.reyesTL4 Admin26 Mar 2026#39

Post #37 put the caveat in the right place and I want to underline it.

How to cite a preprint: author last name, first initial, et al. Title. Server name [preprint]. Posted date. Doi. Include the server name and note that it is a preprint.

Adding it in case it saves somebody the afternoon it cost me.

14 likes 4mo
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b.oseiTL227 Mar 2026#40

Building on post #39 rather than restating it.

Where a preprint contradicts a published trial, the prior should favour the trial. Where it extends one, the preprint can be genuinely useful.

For what it is worth, the same held on the two occasions I checked.

5 likes 4mo
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bias_varianceTL4Biostatistician28 Mar 2026#41

Taking post #40 at face value and following it one step further.

The honest position on most preprints in this field is that they are interesting and provisional, and that saying both is not fence-sitting.

17 likes 4mo
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d.ferreiraTL228 Mar 2026#42
d.oyelaran, post #12: The honest position on most preprints in this field is that they are interesting and provisional, and that saying both is not fence-sitting. Two people can read the same figure differently here and both be reasonable. Go to post

Post #38 and I disagree about the size of the effect, not about the direction.

If you cite a preprint in a maintained document here, the convention is to label it in the sentence and to note the check date. The document review will catch the update.

0 likes in reply to #12 4mo
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batchlogTL3Regular29 Mar 2026#43

Unrefereed work is not worthless and a great deal of it survives review substantially unchanged. That is the accurate framing and it is not a licence to treat it as final.

Adding this to the thread rather than to the wiki, because I am not confident enough for the wiki.

0 likes 4mo
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c.chowdhuryTL229 Mar 2026#44
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compounding_ruthTL4Pharmacist30 Mar 2026#45

Building on post #43 rather than restating it.

Author track record is a weak signal and it is a signal. A group that has published carefully for years is a different prior from an unknown one.

I have no interest in any supplier named above.

24 likes 4mo
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i.norgaardTL230 Mar 2026#46
baseline_drift, post #18: Building on post #17 rather than restating it. Peer review catches some things reliably — missing methods, unsupported conclusions, statistical mistakes of the obvious kind — and misses others routinely. Knowing which is which makes preprint reading easier. Go to post

A preprint with the data and code attached is frequently more checkable than a published paper without them. Reviewed and reproducible are different properties.

I have deliberately not rounded that, because the rounding is where the argument starts.

0 likes in reply to #18 4mo
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impurity_tableTL3Analytical chemist31 Mar 2026#47

What changes between preprint and publication: authors respond to reviewer comments, re-analyse data, correct errors found in peer review, and sometimes report different results from updated analyses. The published version is not the same as the preprint.

1 like 4mo
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s.ostergaardTL21 Apr 2026#48

This is the first time the answer has come with its own limits attached. Appreciated.

7 likes 4mo
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a.thorneTL21 Apr 2026#49
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j.sandvikTL22 Apr 2026#50

Author track record is a weak signal and it is a signal. A group that has published carefully for years is a different prior from an unknown one.

Reading it back, the second half matters more than the first.

18 likes 4mo
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a.eriksenTL22 Apr 2026#51

Sample size and pre-registration are checkable in a preprint exactly as in a paper, and they carry the same weight.

31 likes 4mo
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BBramleyTL3Regular3 Apr 2026#52

Adding a note of thanks rather than an opinion. I did not know most of that.

15 likes 4mo
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c.serranoTL23 Apr 2026#53

How to cite a preprint: author last name, first initial, et al. Title. Server name [preprint]. Posted date. Doi. Include the server name and note that it is a preprint.

Stating my assumptions rather than smuggling them in.

6 likes 4mo
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t.nardoneTL3Regular4 Apr 2026#54
KLindqvist, post #14: That is clearer than the version I had in my head. Thank you. Go to post

Where a preprint contradicts a published trial, the prior should favour the trial. Where it extends one, the preprint can be genuinely useful.

One case, stated as one case.

1 like in reply to #14 4mo
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i.amankwahTL25 Apr 2026#55

Post #53 put the caveat in the right place and I want to underline it.

Building anything durable on a preprint means committing to rebuild it. That is a reasonable trade for a fast-moving question and it should be an explicit one.

0 likes 4mo
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j.vandermolenTL35 Apr 2026#56
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b.correiaTL26 Apr 2026#57
BGiordano, post #34: Adding the measurement that post #31 says would settle it. Where a preprint contradicts a published trial, the prior should favour the trial. Where it extends one, the preprint can be genuinely useful. None of the above is medical advice and I am not qualified to give any. Go to post

Preprints for speed: some important preliminary findings are posted as preprints to disseminate quickly. That speed is useful but comes at the cost of not yet having survived peer review. The trade-off is real.

Anyone with a larger sample, please post it.

10 likes in reply to #34 4mo
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g.valckenaereTL3Regular6 Apr 2026#58
coldchain_liu, post #21: Where a preprint contradicts a published trial, the prior should favour the trial. Where it extends one, the preprint can be genuinely useful. Go to post

Peer review as a filter: published papers have survived a review process that rejects many submissions. Preprints have not. Neither guarantees correctness, but publication history is a difference worth noting.

3 likes in reply to #21 4mo
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a.hartmannTL27 Apr 2026#59
batchlog, post #43: Unrefereed work is not worthless and a great deal of it survives review substantially unchanged. That is the accurate framing and it is not a licence to treat it as final. Adding this to the thread rather than to the wiki, because I am not confident enough for the wiki. Go to post

Post #57 and I disagree about the size of the effect, not about the direction.

A preprint with the data and code attached is frequently more checkable than a published paper without them. Reviewed and reproducible are different properties.

Take it as a starting point and not as a specification.

16 likes in reply to #43 4mo
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excursion_checkTL3Regular7 Apr 2026#60

Say it is a preprint in the first line rather than the last. Everything downstream depends on that status and readers arriving from search will not scroll for it.

Someone should write this up properly, and it should probably not be me.

6 likes 4mo