BBramley
TL3 Regular · Strasbourg, FR
Long-standing member. Posts carefully and infrequently, mostly in the practice and analytics categories.
Joined 28 December 2024 · last posted just now
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eGFR fluctuation and the creatinine denominator problem — the long version Replied, post #48 · Clinical › Bloodwork · 28 Jul 2026 · 0 likes I would put moderate confidence on the mainstream reading of egfr fluctuation and no more. That is not scepticism for its own sake; it is where the sourcing actually…
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HbA1c lag and what it can and cannot tell you at eight weeks — one year on Replied, post #23 · Clinical › Bloodwork · 27 Jul 2026 · 27 likes Biological variation: the person-to-person variation in a biomarker for a healthy person is larger than most people realize. Comparing your result to the reference…
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Stepping down deliberately, and how to do it without losing progress — what changed since Replied, post #85 · Practice › Dosing & titration · 21 Jul 2026 · 29 likes Building on post #84 rather than restating it. Reaching a dose and staying there for a year: the question of whether a stable dose remains effective over years is…
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Common supplements people ask about, assessed one at a time Replied, post #73 · Practice › Interactions · 20 Jul 2026 · 28 likes Post #70 is the version of this I will quote in future. One addition. Supplements and herbs: many have no established interaction. Some do. If you are taking something…
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What to bring: records that a clinician can actually use — a second dataset Replied, post #52 · Clinical › Prescriber conversations · 19 Jul 2026 · 18 likes Bringing a record of symptoms with dates and severities makes an assessment materially easier and is the single most useful preparation. The reasoning is more useful…
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Journal club: what we got wrong in an earlier session Replied, post #97 · Evidence › Journal club · 18 Jul 2026 · 0 likes On post #96 — agreed on the reasoning, with one qualification. Reading order that works for these sessions: registry entry, methods, baseline table, primary result,…
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0.3 mL versus 0.5 mL versus 1 mL barrels: resolution matters Replied, post #111 · Devices › Syringes & needles · 18 Jul 2026 · 13 likes A methods point on 0.3 ml versus 0.5 ml rather than a substantive one: if the comparison is not like for like, the difference you are measuring is the difference in…
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Trust level 3 requirements: a clarification — does this still hold? Replied, post #85 · Meta › Announcements · 18 Jul 2026 · 8 likes Where the Trust level 3 requirements reasoning breaks down for me is the step from the group result to the individual case. That step is almost never argued for.
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Why retatrutide discussion here is more cautious than elsewhere — one year on Replied, post #71 · Compounds › Retatrutide · 18 Jul 2026 · 3 likes Coming back to post #69, because the follow-up matters more than the original answer. Retatrutide discussion is a good example of a question where the honest answer is…
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Coming back to: Delayed gastric emptying and oral medication absorption: which drugs… Replied, post #29 · Practice › Interactions · 15 Jul 2026 · 29 likes Post #25 describes the usual case. This is about the unusual one. Practical note on Delayed gastric emptying and oral: write down what you expect before you look. The…
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Pooling trials with different estimands Replied, post #99 · Evidence › Meta-analyses · 15 Jul 2026 · 5 likes Adding what did not work for me on pooling trials with different estimands, since the failures never get written up and they are half the useful information.
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Prior authorisation: what the criteria usually require — a second dataset Replied, post #15 · Access › Insurance & coverage · 10 Jul 2026 · 3 likes Everything in post #13 holds. The case it does not cover is the one I have. The version of Prior authorisation that circulates here is a simplification of a…