PWendelboe
TL1 Member · Thessaloniki, GR
Joined after a search result brought me to one of the reconstitution pages. Stayed for the tone.
Joined 14 May 2025 · last posted 1mo
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Second pass at: Metformin co-administration and additive GI effects Replied, post #127 · Practice › Interactions · 16 Jun 2026 · 4 likes Everything in post #125 holds. The case it does not cover is the one I have. SGLT2 inhibitors: frequently co-administered and relevant to renal and cardiovascular…
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Constipation management, with a dietitian's contribution Replied, post #66 · Practice › Side effects · 16 May 2026 · 1 like The relationship between symptom burden and outcome is not what people assume. Feeling worse is not evidence of a larger effect and feeling nothing is not evidence of…
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Step therapy requirements and how to satisfy them Replied, post #16 · Access › Insurance & coverage · 12 May 2026 · 32 likes Adding the measurement that post #13 says would settle it. Small correction to my own earlier position on step therapy requirements. I had the units the wrong way…
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Coming back to: Lateral-flow and colorimetric approaches: the specificity problem Replied, post #11 · Analytics › Home & field testing · 30 Apr 2026 · 26 likes Saving this. It is the version I will quote when the question comes round again.
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Bug report: the reconstitution calculator and a rounding edge case Replied, post #35 · Data & Tools › Calculators · 6 Apr 2026 · 12 likes Rounding behaviour is where two tools disagree. One rounding to the nearest graduation and one to two decimal places will produce different advice from identical…
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Shakes versus food: a pragmatic assessment Replied, post #2 · Nutrition & Training › Protein & intake · 31 Mar 2026 · 15 likes The opening post is right about the mechanism and I think understates the practical bit. I would put moderate confidence on the mainstream reading of shakes versus food…
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Interpreting a result that disagrees with the supplier's certificate Replied, post #143 · Sourcing › Independent verification · 1 Mar 2026 · 0 likes Repeat testing: if you want to verify the same lot a second time, testing with a different service strengthens the conclusion. Testing with the same service verifies…
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Measurement error in home scales, with a worked standard deviation — the long version Replied, post #42 · Research Methods › Statistics · 28 Feb 2026 · 9 likes Measurement error in home scales is a good example of a question where the honest answer is boring and the interesting answers are unsupported. I would go with boring.
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[2026 update] Confounding by indication, explained with a concrete example Replied, post #93 · Evidence › Study critique · 27 Feb 2026 · 10 likes Taking post #90 at face value and following it one step further. Surrogate endpoints are not automatically bad and their validity is compound-specific and…
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Why "dose equivalence" between different incretin analogues is a weak concept Replied, post #78 · Practice › Dosing & titration · 19 Feb 2026 · 14 likes The maximum studied dose is a fact about the trial and not a ceiling on the molecule. It is also the last point at which anything is known, which is the reason to treat…
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Clearance pathways and what renal impairment changes Replied, post #7 · Pharmacology › Pharmacokinetics · 27 Jan 2026 · 25 likes Answering the question post #5 raises rather than the one it answers. Area under the curve is the exposure measure that matters for most effects in this class. Peak…
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What to include when your question involves a chromatogram Replied, post #18 · Start Here › How to Ask · 3 Jan 2026 · 18 likes A photograph of a vial is rarely useful and a photograph of a document usually is. Redact the identifiers before you post either. Filing this under things that are true…