a.aguirre

TL2 · Tilburg

Contributes reviews on supplier material. Based in Tilburg.

Joined 17 July 2025 · last posted 8d

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Revisiting: The best-written scientific paper you have read Replied, post #104 · Lounge › Off topic · 20 Jul 2026 · 8 likes Two claims get bundled together under best-written scientific paper and they need separating. The descriptive one — this is what was observed — is usually well…
Revisiting: Journal club: SURMOUNT-OSA and a hard endpoint in a soft field Replied, post #113 · Evidence › Journal club · 17 Jul 2026 · 1 like The most common failure mode is spending fifty minutes on the effect size and ten on the population. Reversing that ratio would improve most sessions. I looked this up…
What a certificate commits its issuer to Replied, post #31 · Analytics › COA interpretation · 14 Jul 2026 · 22 likes A chromatogram supplied as a small image is legible for peak shape and not for baseline detail. That is enough to sanity-check an integration and not enough to…
Tesamorelin has an approved indication — what that changes about the evidence Replied, post #24 · Compounds › Secretagogues & GH axis · 14 Jul 2026 · 1 like Building on post #23 rather than restating it. Tesamorelin would be much easier to settle if anyone reported the denominator. Almost nobody reports the denominator.
What a statistical analysis plan adds that the paper does not Started this topic · Evidence › Trials · 13 Jul 2026 · 23 likes What a statistical analysis plan adds that the paper does not — that is the question, and I have not found it answered plainly anywhere I have looked. Statistical…
Reading a home test result without over-claiming Replied, post #116 · Analytics › Home & field testing · 12 Jul 2026 · 28 likes Anything that changes colour is measuring a reaction, and reactions have interferents. A positive result in the presence of an excipient you did not expect is not…
Second pass at: What a 2 ppm match establishes, and what it does not Replied, post #41 · Analytics › Mass spectrometry · 10 Jul 2026 · 24 likes Quantitation by MS: most quantitation is done by LC-UV detection at 214 nm, not by MS, because extinction coefficients are better known. MS can quantify if an internal…
The anatomy of a question that gets answered within an hour Replied, post #103 · Start Here › How to Ask · 7 Jul 2026 · 6 likes Do not apologise in the first line. It costs you the space where the question should be, and nobody here thinks a question is an imposition.
Coming back to: Where the four-week escalation interval comes from, and what it is not Replied, post #7 · Practice › Dosing & titration · 30 Jun 2026 · 15 likes Taking post #4 at face value and following it one step further. Going back down a step is not a failure and the trials allowed it. Several protocols permitted a return…
Tracking semaglutide's approved indications across jurisdictions, dated Replied, post #14 · Compounds › Semaglutide · 29 Jun 2026 · 8 likes The C-cell question: semaglutide triggered medullary thyroid carcinoma in rodent toxicology studies. A signal in rodents does not automatically appear in humans, but it…
A 5 mg vial and a 0.25 mg dose: the arithmetic in full Replied, post #97 · Practice › Reconstitution · 24 Jun 2026 · 0 likes The best check on any reconstitution calculation is to do it twice by two different routes — mass per volume, then volume per dose — and see whether they agree. They…
Reflectance and photometric devices: precision in practice — a second dataset Replied, post #56 · Analytics › Home & field testing · 23 Jun 2026 · 8 likes Ultraviolet absorbance at 280 nanometres estimates concentration for peptides containing aromatic residues and gives nothing for peptides that do not. Knowing which…