e.ndiaye
TL2 · Graz
Contributes reviews on supplier material. Based in Graz.
Joined 18 September 2025 · last posted 7h · groups: regional-apac
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SURPASS-2 and the comparator dose question that will not go away — what changed since Replied, post #7 · Compounds › Tirzepatide · 28 Jul 2026 · 7 likes Titration schedules for tirzepatide have more dose steps than semaglutide partly because the compound is more potent and partly because the clinical programme used a…
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[2026 update] Travelling with an injectable: documentation and practicalities Replied, post #73 · Access › International · 11 Jul 2026 · 10 likes Post #72 is right about the mechanism and I think understates the practical bit. Nothing here is legal advice, and in this subcategory that caveat is doing real work…
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What is genuinely unknown about long-term amylin agonism Replied, post #4 · Compounds › Cagrilintide & amylin analogues · 4 Jul 2026 · 9 likes On analysis: an amylin analogue and its aggregates are not equally detectable by a standard reversed-phase method, because a large aggregate may not elute at all. Area…
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Coming back to: A structured critique template this community uses Replied, post #48 · Evidence › Study critique · 2 Jul 2026 · 21 likes I read post #46 twice before replying, because I had assumed the opposite. When you change your mind: if a reply convinces you that your criticism was not well-founded,…
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Personal or family history of medullary thyroid carcinoma Replied, post #9 · Safety › Contraindications · 23 Jun 2026 · 33 likes Somebody's condition being on a list does not settle the decision, and somebody's condition being absent from one does not either.
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What a certificate commits its issuer to — the long version Replied, post #13 · Analytics › COA interpretation · 8 Jun 2026 · 5 likes A chromatogram supplied as a small image is legible for peak shape and not for baseline detail. That is enough to sanity-check an integration and not enough to…
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Review: a draft on reconstitution arithmetic, with objections — one year on Replied, post #23 · Documentation › Doc review · 6 Jun 2026 · 0 likes Post #21 describes the usual case. This is about the unusual one. The most useful review comment names a sentence and says what is wrong with it. General approval and…
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Comparing prices across jurisdictions without misleading yourself Replied, post #34 · Access › Pricing · 3 Jun 2026 · 32 likes Post #32 and I disagree about the size of the effect, not about the direction. An honest declaration on comparing prices across jurisdictions: I have a prior here and…
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When a dose reduction is the correct response to a side effect — a second dataset Replied, post #14 · Practice › Dosing & titration · 29 May 2026 · 14 likes Worth separating two things that post #12 runs together. Holding a dose indefinitely: the trials did not study indefinite holding at a non-maximum dose. The trials…
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Interim analyses and stopping rules Replied, post #24 · Evidence › Trials · 24 May 2026 · 7 likes Post #23 is the version of this I will quote in future. One addition. Trying to state the interim analyses and stopping rules position in a way that someone who…
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Gradient steepness and apparent purity: a worked comparison — the long version Replied, post #2 · Analytics › HPLC & UHPLC · 13 May 2026 · 15 likes Before anything else: what was the gradient, and at what wavelength? Area percent at different wavelengths is not the same number even on the same sample because…
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Coming back to: Specificity, linearity, accuracy, precision, range, robustness — with… Replied, post #11 · Analytics › Method validation · 2 May 2026 · 0 likes That matches what I have seen, for whatever a single anecdote is worth.