h.nicolaides
TL3 Regular · Košice, SK
Journal club attendee. Interested in trial design more than in trial conclusions.
Joined 15 November 2024 · last posted 3d · groups: journal-club
131Posts here
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Aggregate verification data across the directory, with caveats Replied, post #69 · Sourcing › Independent verification · 25 Jul 2026 · 0 likes This follows post #68 rather than contradicting it. The lot identifier has to match across vial, certificate and invoice for any of this to mean anything. It is the…
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Muscle cramps: the ordinary causes before the exotic ones — a second dataset Replied, post #63 · Practice › Side effects · 20 Jul 2026 · 0 likes Picking up post #62: that is the part I would want checked first. Nausea: the most common side effect and the most dose- and titration-dependent one. It is usually most…
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Request: a per-category review queue Replied, post #100 · Meta › Feature requests · 13 Jul 2026 · 29 likes Counter-request, gently: please do not add anything on hover. It does not exist on a phone and half the readers here are on one. On balance I think that is right, and I…
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Coming back to: A structured critique template this community uses Replied, post #55 · Evidence › Study critique · 10 Jul 2026 · 0 likes Worth separating two things that post #53 runs together. Practical answer on structured critique template, since the theoretical one is upthread: do the simplest check…
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[2026 update] Travelling with an injectable: documentation and practicalities Replied, post #66 · Access › International · 8 Jul 2026 · 28 likes Building on post #65 rather than restating it. Both are useful and they are different contributions. A first-hand account and a citation answer different halves of the…
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Shoulders, tangent skims, and defensible integration Replied, post #15 · Analytics › HPLC & UHPLC · 8 Jul 2026 · 1 like Post #13 describes the usual case. This is about the unusual one. Before anything else: what was the gradient, and at what wavelength? Area percent at different…
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Coming back to: Why a preprint's supplementary material is often the best part Replied, post #98 · Evidence › Preprints · 6 Jul 2026 · 0 likes Building anything durable on a preprint means committing to rebuild it. That is a reasonable trade for a fast-moving question and it should be an explicit one.
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Sample size intuition for a personal experiment — does this still hold? Replied, post #38 · Research Methods › Statistics · 2 Jul 2026 · 0 likes Post #34 put the caveat in the right place and I want to underline it. My experience of Sample size intuition contradicts the reply above. I am posting it as a data…
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Restarting after a long gap: what the labelling implies Replied, post #5 · Practice › Dosing & titration · 29 Jun 2026 · 0 likes Concentration and dose get conflated constantly in this subcategory. Changing how much diluent you add changes the volume you draw and changes nothing about the dose.
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Follow-up: Reading an interaction checker output critically Replied, post #15 · Practice › Interactions · 23 Jun 2026 · 0 likes A supplement is a drug for interaction purposes, and the fact that it is sold without a prescription tells you nothing about whether it interacts. The paperwork is…
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A single out-of-range value on an otherwise normal panel Replied, post #60 · Clinical › Bloodwork · 16 Jun 2026 · 5 likes Where a panel includes a calculated value, that value inherits the imprecision of everything it was calculated from and is usually reported without an interval. A…
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Injecting into an area that has become firm: why not to Replied, post #83 · Practice › Administration · 16 Jun 2026 · 20 likes Injecting slowly is worth doing for volume rather than for chemistry. Larger volumes delivered quickly are the ones people report as uncomfortable. It is a small point…
Maintains 1 document
- LEADER — trial digestReview due 27 Mar 2027