Coming back to the opening post, because the follow-up matters more than the original answer.
Reading this PIONEER 6 thread as someone who came in with a fixed view: the third and seventh replies moved me and the confident ones did not.
Understood. Thank you for being specific about the limits of it.
Appreciated. The plain phrasing does more work here than a longer post would.
Marking my uncertainty on PIONEER 6 explicitly. I am confident about the direction, much less confident about the size, and not confident at all that it generalises past the case in the first post.
Read the full topic (19 posts)
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Journal club: SELECT, absolute risk, and how it was reported
Journal club: SELECT, absolute risk, and how it was reported Writing it up because I had to work it out twice and would rather nobody else did. A question about what the numbers mean rather than what they…
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2 | 52k | 1mo | |
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Journal club: STEP 3 and the intensive behavioural therapy floor
Posting this under the heading it deserves: Journal club: STEP 3 and the intensive behavioural therapy floor Everything below is what sits behind that. Two things I would like separated before anyone answers…
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+6 | 10 | 13k | 28d |
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Follow-up: Journal club: orforglipron phase 2 and the non-peptide question
Posting this under the heading it deserves: Journal club: orforglipron phase 2 and the non-peptide question Everything below is what sits behind that. A follow-up question about orforglipron phase 2 that I…
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+80 | 91 | 10k | 11mo |
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Second pass at: Journal club: LEADER as the historical anchor
Posting this under the heading it deserves: Second pass at: Journal club: LEADER as the historical anchor Everything below is what sits behind that. Two things I would like separated before anyone answers on…
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+75 | 81 | 2k | 2y |
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Journal club: the CagriSema phase 2 combination paper — a second dataset
Journal club: the CagriSema phase 2 combination paper — a second dataset — setting out what I have, and where I think it stops being reliable. Posting a small dataset on CagriSema phase 2 combination paper.…
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+74 | 79 | 2.3k | 13mo |
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Follow-up: Journal club: the retatrutide phase 2 obesity paper
On the subject in the title: Journal club: the retatrutide phase 2 obesity paper Working notes rather than a conclusion. A follow-up question about retatrutide phase 2 obesity paper that I did not know to ask…
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+20 | 24 | 8.7k | 16mo |
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Journal club: SELECT, absolute risk, and how it was reported — a second dataset
On the subject in the title: Journal club: SELECT, absolute risk, and how it was reported — a second dataset Working notes rather than a conclusion. Posting a small dataset on SELECT. It is mine, it is…
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4 | 1.3k | 1mo | |
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Correlation in a self-tracked dataset: what it can support
Correlation in a self-tracked dataset: what it can support — setting out what I have, and where I think it stops being reliable. Posting a small dataset on correlation. It is mine, it is uncontrolled, and the…
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+152 | 166 | 48k | 23mo |
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Measurement error in home scales, with a worked standard deviation
Measurement error in home scales, with a worked standard deviation Writing it up because I had to work it out twice and would rather nobody else did. What changes if the standard account of measurement error…
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+26 | 31 | 4.3k | 4mo |
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Journal club: SURMOUNT-4 and continuation versus withdrawal — a second dataset
Posting this under the heading it deserves: Journal club: SURMOUNT-4 and continuation versus withdrawal — a second dataset Everything below is what sits behind that. Posting a small dataset on SURMOUNT-4 and…
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+58 | 64 | 17k | 13mo |