The Peptide CommonsEst. May 2024
Independent. We sell nothing and are affiliated with no manufacturer or pharmacy. Every moderation action is logged in public
Evidence · Journal club

About the Journal club category

Pinned Wiki
K
KLindqvistTL4 Moderator5 Dec 2024#1
Community wiki post. Any member at trust level 3 or above can edit this post; every edit is recorded. Last edited by hana.sato on 27 Feb 2025.
  • 10 Feb 2025 — KLindqvist: Restructured into sections so the outline is navigable.
  • 26 May 2025 — mira.patel: Added the limitations paragraph that review asked for.
  • 27 Feb 2025 — hana.sato: Corrected an arithmetic slip in the second example.
Editors: KLindqvist, mira.patel, hana.sato
Staff post. Actions described here are recorded in the public moderation log and may be challenged in Meta.

Our recurring session. One named paper per topic, methods first, conclusions last. Everyone reads before posting.

This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with its author and a note. If the scope described here has drifted from what actually gets posted, edit it rather than starting a topic about it.

What belongs here

  • Questions specific to journal club, with the units and the context stated.
  • Reports and datasets, with the collection method stated.
  • Disagreement about the substance, conducted in public.

What belongs elsewhere

  • Anything urgent belongs in Safety, immediately, and not here.
  • Anything about how this site works belongs in Meta.
  • Requests for a maintained page belong in Wiki requests.

Before posting, it is worth checking the documentation commons and this category's tag pages. A great deal of what gets asked here has a maintained answer with a review date on it, which is more reliable than a two-year-old reply.

10 likes 20mo
HS
hana.satoTL4 Moderator1 Jan 2025#2
Staff post. Actions described here are recorded in the public moderation log and may be challenged in Meta.

Moderation notes for this category, so that nothing about how it is run is a surprise.

Topics get moved into and out of here regularly. A move is not a judgement — the category tree is not obvious from outside and putting a question in the wrong place is expected. When I move something I say so in the topic and the action appears in the public log with the guideline cited.

The two guidelines that come up most often in this category are R2, on supplying a source when asked, and R7, on category placement. Neither is used punitively.

15 likes 19mo
DE
d.eriksenTL220 Jan 2025#3

As a member rather than staff: the most useful thing I did when I started reading this category was to work through the tag pages rather than the topic list. The topic list shows you what is recent. The tags show you what is settled.

0 likes 18mo
MS
m.silvaTL27 Feb 2025#4

Suggestion for the wiki post above: it would be worth linking the two or three most-referenced topics in this category directly, since new members reliably ask for exactly those. Happy to make the edit myself if nobody objects, with a revision note.

0 likes 18mo
CA
c.adebayoTL222 Feb 2025#5
KLindqvist, post #1: Our recurring session. One named paper per topic, methods first, conclusions last. Everyone reads before posting. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with its author and a note. If the scope described here has drifted from what actually gets posted, edit it rather… Go to post

The figures usually contain the finding and the text usually contains the interpretation. Separating them for the first twenty minutes is a discipline worth keeping.

The general case is well covered; this is the awkward specific one.

3 likes in reply to #1 17mo
SD
s.dziedzicTL210 Mar 2025#6
SC
so.cardosoTL224 Mar 2025#7

This follows post #4 rather than contradicting it.

The most common failure mode is spending fifty minutes on the effect size and ten on the population. Reversing that ratio would improve most sessions.

29 likes 16mo

Suggested topics

TopicParticipantsRepliesViewsActivity
Journal club: LEADER as the historical anchor
Journal club: LEADER as the historical anchor Writing it up because I had to work it out twice and would rather nobody else did. What changes if the standard account of LEADER is wrong? I ask because I have…
AKACRIGKR+103 110 8.1k 2h
Journal club: STEP 1 and the treatment-policy estimand — does this still hold?
Asking directly, because I could not find a straight answer: Journal club: STEP 1 and the treatment-policy estimand — does this still hold? Working notes on STEP 1 rather than a conclusion. I would rather…
GKRCDALB+70 76 4.8k 15h
Journal club: SURMOUNT-4 and continuation versus withdrawal — a second dataset
Posting this under the heading it deserves: Journal club: SURMOUNT-4 and continuation versus withdrawal — a second dataset Everything below is what sits behind that. Posting a small dataset on SURMOUNT-4 and…
VMLADNWMD+58 64 17k 13mo
Journal club: the CagriSema phase 2 combination paper
On the subject in the title: Journal club: the CagriSema phase 2 combination paper Working notes rather than a conclusion. CagriSema phase 2 combination paper — I have the observation and I do not trust my…
PFKMM 2 329 21h
Journal club: STEP 4 and what a withdrawal design can prove
On the subject in the title: Journal club: STEP 4 and what a withdrawal design can prove Working notes rather than a conclusion. Session topic: STEP 4 ( JAMA , 2021). Please read it before posting; the…
DJTVGHIO+61 65 2k 13mo

Related topics — sharing the tags journal club, randomised trial, estimand

TopicParticipantsRepliesViewsActivity
Oral semaglutide bioavailability and its variability between people
Posting this under the heading it deserves: Oral semaglutide bioavailability and its variability between people Everything below is what sits behind that. I would like to know what people here actually do…
SHNKITAKAD+44 48 574 3mo
What the GIP component of tirzepatide is thought to contribute, and how confident we can be
What the GIP component of tirzepatide is thought to contribute, and how confident we can be I have a specific reason for asking rather than idle curiosity, and the context is below. I would like to know what…
EFVRCIAKOF+16 20 23k 19h
Comparators chosen for regulatory reasons rather than clinical ones
On the subject in the title: Comparators chosen for regulatory reasons rather than clinical ones Working notes rather than a conclusion. An honest uncertainty about comparators chosen for regulatory reasons…
PESZTD 2 27k 14mo
Semaglutide half-life: where the 165 to 184 hour figure comes from — what changed since
Posting this under the heading it deserves: Semaglutide half-life: where the 165 to 184 hour figure comes from — what changed since Everything below is what sits behind that. Putting the numbers in the first…
HBADNVPNCH+125 132 39k 16mo
[2026 update] How to read a forest plot, properly, from scratch
How to read a forest plot, properly, from scratch — that is the question, and I have not found it answered plainly anywhere I have looked. Reading SURMOUNT-4 ( JAMA , 2024) for the population rather than the…
AZVNLWFKK+49 53 643 19mo