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Wellbeing · Mental health

Anxiety in the first weeks: drug, situation, or both — what changed since

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BV
bias_varianceTL4Biostatistician16 Jun 2025#1

Anxiety in the first weeks: drug, situation, or both — what changed since Writing it up because I had to work it out twice and would rather nobody else did.

The question about Anxiety that I actually want answered is the second one below. The first is context and I have kept it short.

Both are stated with units, and I have said what I already checked so that nobody repeats it.

1 like 13mo
SM
s.mbekiTL224 Jun 2025#2

Tracking mood alongside dose and weeks, on a simple scale, produces a record that is far more useful than a recollection at an appointment.

0 likes 13mo
DH
dietitian_hollisTL3Dietitian29 Jun 2025#3
s.mbeki, post #2: Tracking mood alongside dose and weeks, on a simple scale, produces a record that is far more useful than a recollection at an appointment. Go to post

I read the opening post twice before replying, because I had assumed the opposite.

I have been on both sides of the Anxiety argument in this category within eighteen months, which should tell you how strong the evidence for either side is.

2 likes in reply to #2 13mo
HA
h.agyemanTL24 Jul 2025 · edited#4
dietitian_hollis, post #3: I read the opening post twice before replying, because I had assumed the opposite. I have been on both sides of the Anxiety argument in this category within eighteen months, which should tell you how strong the evidence for either side is. Go to post

The opening post answers the question as asked. The question underneath it is different.

One caution on Anxiety: everything above assumes the underlying documentation is what it claims to be. That assumption is doing real work and is rarely stated.

4 likes in reply to #3 13mo
BN
bench_notesTL4 Moderator8 Jul 2025#5

This is the answer, and the reason it is the answer is the more useful part.

1 like 13mo
VB
v.baptistaTL212 Jul 2025 · edited#6

Expectations set by other people's reported trajectories are a documented source of distress, and the trajectories posted are not representative.

I am confident about the direction and much less about the magnitude.

0 likes 13mo
PW
PharmNotes_WhitfieldTL4Pharmacist16 Jul 2025#7

Everything in post #6 holds. The case it does not cover is the one I have.

On Anxiety, I would rather understate and be corrected upward than overstate and be quoted. That is a house style here and it is a good one.

18 likes 12mo
SC
s.cabreraTL220 Jul 2025#8
bench_notes, post #5: This is the answer, and the reason it is the answer is the more useful part. Go to post

Reading this Anxiety thread as someone who came in with a fixed view: the third and seventh replies moved me and the confident ones did not.

7 likes in reply to #5 12mo
NE
n.ekstromTL2Regular23 Jul 2025#9
s.mbeki, post #2: Tracking mood alongside dose and weeks, on a simple scale, produces a record that is far more useful than a recollection at an appointment. Go to post

On post #6 — agreed on the reasoning, with one qualification.

Support and community: some people process weight change through community (online or in-person). Others prefer privacy. Knowing what you need and seeking it proactively helps.

Genuinely open to being wrong about this one.

13 likes in reply to #2 12mo
SV
s.vukovicTL227 Jul 2025#10

Picking up post #9: that is the part I would want checked first.

I would be cautious about generalising from the Anxiety example above. It is a good example. It is one example.

4 likes 12mo
ID
i.dumitruTL230 Jul 2025#11
bench_notes, post #5: This is the answer, and the reason it is the answer is the more useful part. Go to post

Mood and anxiety: mood changes and anxiety are reported by some people. Baseline mental health status matters for risk. Someone with a history of depression should plan closer monitoring.

Reporting the observation and leaving the explanation open deliberately.

0 likes in reply to #5 12mo
EL
endpoint_lineTL3Regular3 Aug 2025#12

Worth stating the null on Anxiety before we explain it: the observation may be nothing. That possibility deserves a sentence and usually does not get one.

4 likes 12mo
IG
in.guerreroTL26 Aug 2025#13

Confirming post #10 from a second method, which matters more than confirming it from a second person.

My position on Anxiety is current rather than settled. I have revised it once already and I expect to again, so treat it accordingly.

18 likes 12mo
HN
h.nicolaidesTL3Regular9 Aug 2025#14

Nothing here is medical advice and several members in this subcategory say plainly that they are describing their own experience only.

0 likes 12mo
AC
a.cabreraTL212 Aug 2025#15
bench_notes, post #5: This is the answer, and the reason it is the answer is the more useful part. Go to post

Checked the Anxiety claim against the primary source this morning. It survives, with a narrower scope than the version quoted here. Posting the narrower scope.

1 like in reply to #5 12mo
C
CFairweatherTL1Member15 Aug 2025#16

When to involve a professional: if mood changes are persistent, deepen over weeks, or interfere with function, involving a mental health professional is appropriate. These are not trivialities to ignore.

Adding the caveat now so it does not have to be extracted later.

7 likes 11mo
SD
s.demirTL219 Aug 2025#17

Post #14 is the version of this I will quote in future. One addition.

Support here is genuine and is not a substitute for care, and saying both is not a contradiction.

This is the version I would want a new member to read first.

25 likes 11mo
R
RidgewayTL3Regular22 Aug 2025#18
s.demir, post #17: Post #14 is the version of this I will quote in future. One addition. Support here is genuine and is not a substitute for care, and saying both is not a contradiction. This is the version I would want a new member to read first. Go to post

Where I part company with post #16, and it is a narrow parting.

Anxiety came up in a thread eighteen months ago and was answered well. I cannot find it, which is itself the problem, so here is the reconstruction.

0 likes in reply to #17 11mo
ZS
z.szaboTL225 Aug 2025#19

The arithmetic in post #18 is right; the assumption feeding it is the part to check.

Motivation and expectation: starting with clear motivation and realistic expectations about what will happen and when helps with psychological adjustment.

4 likes 11mo
KR
k.redgraveTL2Member28 Aug 2025 · edited#20

Answering the question post #16 raises rather than the one it answers.

I have three months of notes on Anxiety and the honest summary is that the trend is real and the week-to-week numbers are noise. I nearly drew the opposite conclusion from the first fortnight.

12 likes 11mo
GF
gradient_fileTL231 Aug 2025#21
SK
s.kravchenkoTL22 Sep 2025#22

Post #20 is the version of this I will quote in future. One addition.

The social side of this — how other people respond to visible change — comes up constantly and has nothing to do with pharmacology.

Reading it again, the caveat matters more than the finding.

18 likes 11mo
W
WoodhouseTL2Member5 Sep 2025#23

Answering the question post #22 raises rather than the one it answers.

On Anxiety: the maintained page in the documentation commons covers the general case with citations and a review date, which is more reliable than any reply here including this one.

7 likes 11mo
CV
ca.vermeulenTL28 Sep 2025#24

I would put moderate confidence on the mainstream reading of Anxiety and no more. That is not scepticism for its own sake; it is where the sourcing actually stops.

1 like 11mo
R
RidgewayTL3Regular11 Sep 2025#25
bias_variance, post #1: Anxiety in the first weeks: drug, situation, or both — what changed since Writing it up because I had to work it out twice and would rather nobody else did. The question about Anxiety that I actually want answered is the second one below. The first is context and I have kept it short. Both are stated with units, and I have said what I… Go to post

I had written a reply contradicting post #22 and deleted it. Here is what survived.

Maintenance brings a different set of psychological questions from loss, and the discussion here is much thinner on that phase.

It is worth stating the boring hypothesis before the interesting one.

0 likes in reply to #1 11mo
IG
i.grimaldiTL214 Sep 2025#26
k.redgrave, post #20: Answering the question post #16 raises rather than the one it answers. I have three months of notes on Anxiety and the honest summary is that the trend is real and the week-to-week numbers are noise. I nearly drew the opposite conclusion from the first fortnight. Go to post

Confirming post #25 from a second method, which matters more than confirming it from a second person.

Mood changes reported during substantial weight loss have several plausible contributors and the drug is only one of them. Energy restriction alone is a well-documented one.

Somebody will have a better source than mine, and I hope they post it.

25 likes in reply to #20 10mo
EL
endpoint_lineTL3Regular17 Sep 2025 · edited#27

Worth separating Anxiety as a question about the compound from Anxiety as a question about the documentation. They get answered by different people and only one of them is answerable here.

12 likes 10mo
ZA
z.adeyemiTL219 Sep 2025#28

That is clearer than the version I had in my head. Thank you.

4 likes 10mo
RS
r.scholtenTL2Member22 Sep 2025#29

Post #25 and I disagree about the size of the effect, not about the direction.

I keep a log for Anxiety specifically because my memory of it turned out to be systematically wrong in one direction. Six weeks of notes cost nothing and settled it.

19 likes 10mo
GV
g.verhoevenTL225 Sep 2025#30
h.nicolaides, post #14: Nothing here is medical advice and several members in this subcategory say plainly that they are describing their own experience only. Go to post

Social and relationship impacts: weight change affects how others perceive and interact with a person. Those impacts are real and can be psychologically significant.

8 likes in reply to #14 10mo