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Wellbeing · Mental health · continued

Anxiety in the first weeks: drug, situation, or both posts 31–60

This is a continuation of a long topic, addressed by post number rather than by page. Start at post 1.

HB
h.bakkerTL226 Dec 2024#31

Everything in post #29 holds. The case it does not cover is the one I have.

The confident answers on anxiety and the well-sourced answers are not the same answers, which is the most useful thing I have learned reading this category.

0 likes 19mo
MS
m.strand_rphTL3Pharmacist29 Dec 2024#32

I came in to disagree and I am leaving without a disagreement.

25 likes 19mo
CO
c.ostergaardTL21 Jan 2025#33
h.nicolaides, post #29: Expectations set by other people's reported trajectories are a documented source of distress, and the trajectories posted are not representative. Go to post

Maintenance brings a different set of psychological questions from loss, and the discussion here is much thinner on that phase.

12 likes in reply to #29 19mo
HS
hana.satoTL4 Moderator3 Jan 2025 · edited#34
b.nwosu, post #22: Coming back to post #18, because the follow-up matters more than the original answer. Support here is genuine and is not a substitute for care, and saying both is not a contradiction. The claim is narrower than it sounds, and deliberately so. Go to post

Worth separating anxiety as a question about the compound from anxiety as a question about the documentation. They get answered by different people and only one of them is answerable here.

4 likes in reply to #22 19mo
SA
s.antonsenTL26 Jan 2025#35

Mood and anxiety: mood changes and anxiety are reported by some people. Baseline mental health status matters for risk. Someone with a history of depression should plan closer monitoring.

0 likes 19mo
FP
forest_plotTL3Evidence synthesis9 Jan 2025#36

Post #33 answers the question as asked. The question underneath it is different.

Two things can be true about anxiety at once: the mechanism is plausible and the evidence for the size of the effect is thin. Most of the argument here is people defending the first against attacks on the second.

0 likes 19mo
NV
n.villalobosTL212 Jan 2025#37

Small correction to my own earlier position on anxiety. I had the units the wrong way round, which changes the conclusion by an order of magnitude and therefore changes it entirely.

17 likes 18mo
BI
blank_injectionTL2Analytical chemist14 Jan 2025#38
baseline_peak, post #21: Post #20 is right about the mechanism and I think understates the practical bit. Where I would push back on the anxiety consensus is the confidence, not the direction. The direction looks right. The confidence is borrowed. Go to post

If you are in crisis, contact a local emergency or crisis service rather than posting. A volunteer forum cannot help and waiting costs time.

7 likes in reply to #21 18mo
JD
j.dahlbergTL217 Jan 2025#39
baseline_peak, post #21: Post #20 is right about the mechanism and I think understates the practical bit. Where I would push back on the anxiety consensus is the confidence, not the direction. The direction looks right. The confidence is borrowed. Go to post

I disagree with the framing of anxiety above, and I think it is a substantive disagreement rather than a terminological one. Setting out why, so it can be checked.

The reasoning depends on an assumption that is doing a lot of work and is never stated. If the assumption holds, the conclusion follows. I do not think it holds generally.

1 like in reply to #21 18mo
VB
v.bhattacharyaTL220 Jan 2025#40

Nothing here is medical advice and several members in this subcategory say plainly that they are describing their own experience only.

0 likes 18mo
ME
me.eriksenTL222 Jan 2025#41

Two questions I would want answered before drawing anything from the anxiety data above: how were the cases selected, and what happened to the ones that dropped out.

0 likes 18mo
KS
k.salinasTL225 Jan 2025 · edited#42
a.delgado, post #18: Nothing here is medical advice and several members in this subcategory say plainly that they are describing their own experience only. Take the reasoning and check the arithmetic; I do not always get it right. Go to post

On anxiety the community has more anecdote than the confidence in this thread implies, and I include my own contribution in that.

3 likes in reply to #18 18mo
RR
r.restrepoTL227 Jan 2025#43

That is clearer than the version I had in my head. Thank you.

16 likes 18mo
CC
c.correiaTL230 Jan 2025#44

Where I part company with post #40, and it is a narrow parting.

Social and relationship impacts: weight change affects how others perceive and interact with a person. Those impacts are real and can be psychologically significant.

That is all I can say without guessing.

32 likes 18mo
DO
dr_okonkwoTL4 Moderator2 Feb 2025#45

I would keep anxiety and the decision it usually gets used for separate in this thread. They are related and they are not the same question, and merging them is why the last one went badly.

0 likes 18mo
MP
m.perrinTL24 Feb 2025#46
n.norgaard, post #24: Small methodological point on anxiety: repeating a measurement is cheap and resolves most of what is being argued about here at no cost to anyone. Go to post

Post #44 describes the usual case. This is about the unusual one.

Maintenance brings a different set of psychological questions from loss, and the discussion here is much thinner on that phase.

1 like in reply to #24 18mo
DF
d.fontaineTL27 Feb 2025#47
v.bhattacharya, post #40: Nothing here is medical advice and several members in this subcategory say plainly that they are describing their own experience only. Go to post

Confirming post #46 from a second method, which matters more than confirming it from a second person.

Sleep and mental health: these compounds can affect sleep for some people. Sleep deprivation worsens mood and anxiety. Addressing sleep separately from mood matters.

That distinction has done more work for me than anything else in this category.

11 likes in reply to #40 18mo
FS
f.sjobergTL29 Feb 2025#48

Having read the whole anxiety thread before replying: the question in the first post has not actually been answered yet, and three of us have answered a nearby one instead.

24 likes 18mo
RM
ra.mensaTL212 Feb 2025 · edited#49
k.marchand, post #20: Nobody has said the unglamorous part of anxiety yet, so: most of the variation is explained by things that are boring to write about and easy to check. Go to post

Post #46 answers the question as asked. The question underneath it is different.

Mood changes reported during substantial weight loss have several plausible contributors and the drug is only one of them. Energy restriction alone is a well-documented one.

I would put a moderate confidence on that and no more.

3 likes in reply to #20 17mo
JD
j.delacroixTL3Regular14 Feb 2025#50
m.strand_rph, post #32: I came in to disagree and I am leaving without a disagreement. Go to post

I have been on both sides of the anxiety argument in this category within eighteen months, which should tell you how strong the evidence for either side is.

10 likes in reply to #32 17mo
SC
s.chowdhuryTL3Regular17 Feb 2025#51

If you are new and reading this thread for the answer to anxiety: the answer is conditional, the conditions are in the third reply, and the rest of the thread is worth skipping.

0 likes 17mo
AI
an.ibarraTL219 Feb 2025#52
SL
sleep_logTL2Regular22 Feb 2025#53
forest_plot, post #36: Post #33 answers the question as asked. The question underneath it is different. Two things can be true about anxiety at once: the mechanism is plausible and the evidence for the size of the effect is thin. Most of the argument here is people defending the first against attacks on the second. Go to post

I had written a reply contradicting post #51 and deleted it. Here is what survived.

Support here is genuine and is not a substitute for care, and saying both is not a contradiction.

For what it is worth, the same held on the two occasions I checked.

6 likes in reply to #36 17mo
LV
l.vukovicTL224 Feb 2025#54
r.girard, post #25: Tracking mood alongside dose and weeks, on a simple scale, produces a record that is far more useful than a recollection at an appointment. If anyone can point at the primary source I would be grateful. Go to post

My position on anxiety is current rather than settled. I have revised it once already and I expect to again, so treat it accordingly.

1 like in reply to #25 17mo
TH
TL4_HalvorsenTL4Leader · Journal club27 Feb 2025#55

Helpful, and short, which on this subject is harder than long.

0 likes 17mo
RE
r.ekstromTL21 Mar 2025#56

The bit of anxiety that nobody enjoys is that the answer changes depending on what you are trying to decide with it. Say what the decision is and the thread will converge.

30 likes 17mo
FN
formulary_notesTL3Regular3 Mar 2025#57
l.ibarra, post #15: When to involve a professional: if mood changes are persistent, deepen over weeks, or interfere with function, involving a mental health professional is appropriate. These are not trivialities to ignore. Go to post

Coming back to post #56, because the follow-up matters more than the original answer.

Motivation and expectation: starting with clear motivation and realistic expectations about what will happen and when helps with psychological adjustment.

Correct me on the arithmetic if it is wrong; I would rather know.

10 likes in reply to #15 17mo
CA
c.amankwahTL26 Mar 2025 · edited#58

Post #56 is right about the mechanism and I think understates the practical bit.

Offering a way to settle anxiety rather than another opinion about it. Two measurements, taken the same way, a fortnight apart. If the difference is within the noise, the question was not answerable at this precision.

3 likes 17mo
MH
ms_hollowayTL4Mass spectrometrist8 Mar 2025#59

Answering the question post #56 raises rather than the one it answers.

The honest answer on anxiety is that it depends, and the useful part is the list of what it depends on. Four items, in rough order of how much they matter.

Most people get the first two right and then argue about the fourth.

1 like 17mo
MI
m.ibarraTL211 Mar 2025#60

Mood and anxiety: mood changes and anxiety are reported by some people. Baseline mental health status matters for risk. Someone with a history of depression should plan closer monitoring.

0 likes 17mo