Chronic kidney disease and the FLOW result — a second dataset Writing it up because I had to work it out twice and would rather nobody else did.
Posting a small dataset on Chronic kidney disease. It is mine, it is uncontrolled, and the method is stated so it can be discounted appropriately.
What I would like is not agreement but a second dataset collected by someone with no stake in mine. If one exists I would rather read it than argue for this one.
The opening post is the version of this I will quote in future. One addition.
Multiple comorbidities: a person with diabetes, kidney disease, and cardiovascular disease is outside the studied populations in most trials. Extrapolating to that person requires reasoning from the individual component trials and mechanisms.
One of those cases where knowing the mechanism does not help the decision.
Interactions between comorbidities: diabetes and kidney disease together change the risk calculation for hypoglycemia and for medication clearance. They are not independent variables.
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Hepatic steatosis: what the MASH trial evidence supports
Hepatic steatosis: what the MASH trial evidence supports — setting out what I have, and where I think it stops being reliable. Trying to work out what would count as evidence on hepatic steatosis, before…
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+77 | 83 | 950 | 13mo |
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Osteoarthritis and mechanical versus metabolic improvement
Osteoarthritis and mechanical versus metabolic improvement Writing it up because I had to work it out twice and would rather nobody else did. Asking about osteoarthritis and mechanical versus metabolic…
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+2 | 6 | 30k | 12h |
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[2026 update] Gastro-oesophageal reflux: improving or worsening?
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3 | 782 | 13mo | |
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Obstructive sleep apnoea and a hard endpoint in this class
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+120 | 129 | 1.8k | 13mo |
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[2026 update] Cardiovascular risk: reading the outcome trials as a set
Posting this under the heading it deserves: Cardiovascular risk: reading the outcome trials as a set Everything below is what sits behind that. I have spent a fortnight trying to pin Cardiovascular risk down…
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+99 | 103 | 32k | 11mo |
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[2026 update] What a good consultation looks like from the other side
The question in the title: What a good consultation looks like from the other side I will give what I have already checked below so nobody repeats it. Good consultation: what I expected, what I found, and the…
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+32 | 36 | 13k | 1mo |
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What to bring: records that a clinician can actually use
Asking directly, because I could not find a straight answer: What to bring: records that a clinician can actually use A question about how to describe something to a clinician rather than about the thing…
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+15 | 19 | 6.4k | 1d |
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Coming back to: What the published dose-response for semaglutide actually looks like above 2.4 mg
The question in the title: What the published dose-response for semaglutide actually looks like above 2.4 mg I will give what I have already checked below so nobody repeats it. I would like to know what…
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+23 | 27 | 9.9k | 1mo |
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The headache that turns out to be dehydration
The headache that turns out to be dehydration Writing it up because I had to work it out twice and would rather nobody else did. Reporting what I changed and what happened, with the caveat that I changed two…
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+143 | 158 | 7.8k | 6mo |
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When your prescriber and the evidence disagree
When your prescriber and the evidence disagree — that is the question, and I have not found it answered plainly anywhere I have looked. What changes if the standard account of prescriber is wrong? I ask…
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+14 | 18 | 273 | 2d |