Topic summary

Coming back to: GHRH analogues versus ghrelin mimetics: different mechanisms, conflated discussion

Compounds › Secretagogues & GH axis GHRP class ipamorelin CJC-1295 needs a source Closed

This is a generated summary. It shows the 5 most-liked posts from a topic of 14, in their original order, with the accepted answer included where one exists. It is a reading aid and it will miss nuance — the full topic is the record.

bench_notesTL4 Moderator30 May 2024#1

GHRH analogues versus ghrelin mimetics: different mechanisms, conflated discussion Writing it up because I had to work it out twice and would rather nobody else did.

GHRH analogues versus ghrelin mimetics — I have the observation and I do not trust my interpretation of it, so I am posting the observation and holding the interpretation back.

Numbers, method and the conditions under which they were collected are below. Interpret them however they warrant.

33 likes 2.2y

h.mensahTL221 Sep 2024#5

The opening post put the caveat in the right place and I want to underline it.

GHRH analogues versus ghrelin mimetics are often conflated but they are different mechanisms. GHRH analogues (like CJC-1295) cause the pituitary to release growth hormone. Ghrelin mimetics (like GHRPs) act on the ghrelin receptor directly. The effect on growth hormone secretion is similar but the mechanisms are distinct.

24 likes 22mo

h.amankwahTL211 Dec 2024#9

Sermorelin and the growth hormone releasing hormone analogues depend on a functioning pituitary response, which is the mechanistic reason they behave differently in different people rather than a dosing problem.

32 likes 20mo

ThibodeauTL3Regular30 Dec 2024#10

h.mensah, post #5: The opening post put the caveat in the right place and I want to underline it. GHRH analogues versus ghrelin mimetics are often conflated but they are different mechanisms. GHRH analogues (like CJC-1295) cause the pituitary to release growth hormone. Ghrelin mimetics (like GHRPs) act on the ghrelin receptor directly. The effect on… Go to post

Practical experience of GHRH analogues versus ghrelin mimetics, offered as one case with the conditions stated, not as a general finding. Conditions first, because they are what make it interpretable.

17 likes in reply to #5 19mo

BramleyTL2Member18 Jan 2025#11

bench_notes, post #1: GHRH analogues versus ghrelin mimetics: different mechanisms, conflated discussion Writing it up because I had to work it out twice and would rather nobody else did. GHRH analogues versus ghrelin mimetics — I have the observation and I do not trust my interpretation of it, so I am posting the observation and holding the interpretation… Go to post

Taking GHRH analogues versus ghrelin mimetics seriously for a moment rather than deflecting: the honest position is that the community has observations and no controlled comparison, and those two things support very different sentences.

20 likes in reply to #1 18mo

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Why pulsatile secretion matters for interpreting secretagogue claims — a second datasetCompounds › Secretagogues & GH axis · 64 replies

Promoted into the documentation commons. The content of this topic is maintained at Growth-hormone-releasing peptides (GHRP class) — reference, with named maintainers and a review date. The promotion was discussed in doc review. Corrections are best raised against the document, which is the version that gets kept current.

This topic was closed 90 days after the last reply. Closing is automatic for quiet topics so that a settled answer does not collect new questions underneath it. If you have a follow-up, open a new topic and link back to this one — that keeps both readable and gives your question its own title.

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