This is a continuation of a long topic, addressed by post number rather than by page. Start at post 1.
The documentation on high-resolution is better than this thread and I say that as someone who has posted in the thread.
Reframing high-resolution slightly, because I think the disagreement is about the question rather than the answer. If the question is "does it happen", yes. If it is "how often", nobody here knows.
On post #119 — agreed on the reasoning, with one qualification.
Resolution: "high resolution" commonly means <5 ppm across the mass range. Unit-resolution instruments achieve ±1 Da at best and cannot distinguish two species differing by less than 1 Da in total mass.
Picking up post #123: that is the part I would want checked first.
Resolution and mass accuracy are different specifications. An instrument can resolve two species and still assign their masses imprecisely, and the reverse is also possible.
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