Osteoarthritis and mechanical versus metabolic improvement

Osteoarthritis and mechanical versus metabolic improvement Writing it up because I had to work it out twice and would rather nobody else did.

Asking about osteoarthritis and mechanical versus metabolic directly, because I have read four threads on it and each answered a slightly different question.

The version I want answered is the narrow one: given the method stated below, is the result within what anyone else has seen? I am not asking what it means yet.

Method, numbers and the two assumptions I am aware of making are below. If the assumptions are wrong that is more useful to me than agreement.

PCOS and metabolic overlap: polycystic ovary syndrome has metabolic overlap with obesity and insulin resistance. Data on compounds in this class in PCOS specifically is thin; most discussion is by mechanism.

My experience of osteoarthritis and mechanical versus metabolic contradicts the reply above. I am posting it as a data point rather than as a refutation, because one person's experience is exactly that.

Worth separating two things that the opening post runs together.

The question underneath osteoarthritis and mechanical versus metabolic is usually "how would I tell?" rather than "what is true?", and that one has a method attached to it.

Write down what you would expect to see under each hypothesis before you collect anything. If they predict the same observation, collecting it will not help.

Agreed, and I will stop repeating the version of this I had been repeating.