Particulates in a reconstituted solution: identifying the likely source — what changed since — setting out what I have, and where I think it stops being reliable.
What changes if the standard account of Particulates is wrong? I ask because I have been treating it as settled and I noticed this week that I could not say why.
Working through the consequences rather than the evidence, since others here are better placed on the evidence.
Answering the question the opening post raises rather than the one it answers.
Truncation products are substantially lower in mass and usually well separated chromatographically, which makes them the easiest class to see and the least likely to be missed.
If anyone can point at the primary source I would be grateful.
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Residual solvents and scavengers: what is looked for
On the subject in the title: Residual solvents and scavengers: what is looked for Working notes rather than a conclusion. I would like to know what people here actually do about residual solvents and…
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+19 | 23 | 39k | 14mo |
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Endotoxin and why it is a separate question from purity — what changed since
On the subject in the title: Endotoxin and why it is a separate question from purity — what changed since Working notes rather than a conclusion. What changes if the standard account of Endotoxin is wrong? I…
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+78 | 91 | 1k | 10h |
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Second pass at: Where impurities in solid-phase peptide synthesis come from
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+47 | 51 | 3.3k | 5mo |
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Oxidation pathways for methionine and tryptophan
Posting this under the heading it deserves: Oxidation pathways for methionine and tryptophan Everything below is what sits behind that. Working notes on oxidation pathways for methionine rather than a…
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+58 | 63 | 1k | 19mo |
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Revisiting: Aggregates and why a purity assay may miss them entirely
Posting this under the heading it deserves: Revisiting: Aggregates and why a purity assay may miss them entirely Everything below is what sits behind that. I would like to disagree carefully with the settled…
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+48 | 53 | 918 | 8mo |
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Endotoxin and why it is a separate question from purity — what changed since
On the subject in the title: Endotoxin and why it is a separate question from purity — what changed since Working notes rather than a conclusion. What changes if the standard account of Endotoxin is wrong? I…
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+78 | 91 | 1k | 10h |
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Aggregates and why a purity assay may miss them entirely
Aggregates and why a purity assay may miss them entirely Writing it up because I had to work it out twice and would rather nobody else did. I would like to disagree carefully with the settled view on…
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+61 | 69 | 2.9k | 6mo |
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Isotope patterns and why the monoisotopic peak is not the tallest — does this still hold?
Isotope patterns and why the monoisotopic peak is not the tallest — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. Asking about Isotope patterns…
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2 | 4.6k | 7h | |
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Shoulders, tangent skims, and defensible integration — the long version
Shoulders, tangent skims, and defensible integration — the long version Writing it up because I had to work it out twice and would rather nobody else did. Setting out an integration problem with the actual…
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+16 | 20 | 27k | 3mo |
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[2026 update] Reading a chromatogram someone posted without axes
Posting this under the heading it deserves: Reading a chromatogram someone posted without axes Everything below is what sits behind that. Reading a chromatogram, from the point of view of someone who has read…
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2 | 59 | 2mo |