Compounds · Cagrilintide & amylin analogues · continued

The CagriSema phase 2 paper and what a fixed combination buys posts 91–94

Compounds › Cagrilintide & amylin analogues randomised trial cagrilintide effect size

This is a continuation of a long topic, addressed by post number rather than by page. Start at post 1.

d.bramleyTL3Regular31 Aug 2025 · edited#91

cannula_drift, post #42: Published human data on cagrilintide alone is thinner than on the combination, which is the reverse of what most people assume from how it is discussed here. Go to post

Where I part company with post #89, and it is a narrow parting.

Gastric emptying: both amylin and GLP-1 slow it, through partly overlapping but distinct mechanisms. Whether the slowing at a higher magnitude produces disproportionate nausea or is tolerable is a question phase 3 exists to answer.

That holds under the stated conditions and I have stated them.

22 likes in reply to #42 11mo

a.nascimentoTL22 Sep 2025#92

Cagrisema phase 2 paper is well covered in the tag pages, and the older discussions are better than the recent ones because they were argued out properly. Worth twenty minutes before adding to this one.

10 likes 11mo

k.brandl_deTL3Translator · DE4 Sep 2025#93

If someone has run cagrisema phase 2 paper properly I would rather read that than my own reconstruction of it. Posting mine only because the thread has gone quiet.

3 likes 11mo

a.teixeiraTL26 Sep 2025#94

b.vestergaard, post #74: Nausea appears in the amylin-analogue literature as it does in the incretin literature, and the two are not additive in a simple way when the drugs are combined. The combination trials report tolerability separately for that reason. Go to post

Following this. I have the same question and no better information than the first post.

0 likes in reply to #74 11mo

Suggested topics

Topic	Participants	Replies	Views	Activity
The CagriSema phase 2 paper and what a fixed combination buys — the long version Compounds › Cagrilintide & amylin analogues amylin analogues cagrisema cagrilintide The CagriSema phase 2 paper and what a fixed combination buys — the long version Writing it up because I had to work it out twice and would rather nobody else did. A narrow question about CagriSema phase 2…	+137	158	17k	13mo
Nausea profile of amylin analogues compared with GLP-1 agonists Compounds › Cagrilintide & amylin analogues cagrilintide amylin analogues cagrisema Nausea profile of amylin analogues compared with GLP-1 agonists Writing it up because I had to work it out twice and would rather nobody else did. I have spent a fortnight trying to pin nausea profile of…	+70	76	3k	4mo
[2026 update] Amylin and gastric emptying: overlapping mechanisms with incretins Compounds › Cagrilintide & amylin analogues amylin analogues randomised trial effect size cagrisema Amylin and gastric emptying: overlapping mechanisms with incretins — setting out what I have, and where I think it stops being reliable. A question about Amylin and gastric emptying that I think has a…	+21	25	44k	5mo
Coming back to: Amylin analogue mechanism: satiety signalling separate from GLP-1 Compounds › Cagrilintide & amylin analogues cagrisema effect size randomised trial cagrilintide On the subject in the title: Amylin analogue mechanism: satiety signalling separate from GLP-1 Working notes rather than a conclusion. Trying to work out what would count as evidence on Amylin analogue…	+27	31	671	12mo
Historical amylin analogues and what happened to them Compounds › Cagrilintide & amylin analogues randomised trial cagrilintide cagrisema effect size Posting this under the heading it deserves: Historical amylin analogues and what happened to them Everything below is what sits behind that. Proposing that historical amylin analogues deserves a maintained…	+29	36	31k	1d

Related topics — sharing the tags randomised trial, cagrilintide, effect size

Topic	Participants	Replies	Views	Activity
The most common factual error about semaglutide on the internet — what changed since Compounds › Semaglutide effect size randomised trial SELECT trial type 2 diabetes The most common factual error about semaglutide on the internet — what changed since — setting out what I have, and where I think it stops being reliable. Putting the numbers in the first post, because a…	+42	46	1.7k	5mo
Regression to the mean in progress reports Research Methods › Statistics number needed to treat heterogeneity confounding effect size On the subject in the title: Regression to the mean in progress reports Working notes rather than a conclusion. Something about regression does not reconcile and I would like a second pair of eyes before I…	+30	34	49k	12mo
Criticising the method without criticising the authors — one year on Evidence › Study critique confounding effect size disputed risk of bias Solved Closed On the subject in the title: Criticising the method without criticising the authors — one year on Working notes rather than a conclusion. A methods question rather than a substantive one, about Criticising…	+16	20	61k	11mo
Comparing my trajectory with the trial curves, carefully Outcomes › Progress reports DXA effect size long read data table Solved Posting this under the heading it deserves: Comparing my trajectory with the trial curves, carefully Everything below is what sits behind that. Maintenance rather than loss, which is the part of this that…	+86	92	54k	7mo
The CagriSema phase 2 paper and what a fixed combination buys — the long version Compounds › Cagrilintide & amylin analogues amylin analogues cagrisema cagrilintide The CagriSema phase 2 paper and what a fixed combination buys — the long version Writing it up because I had to work it out twice and would rather nobody else did. A narrow question about CagriSema phase 2…	+137	158	17k	13mo