Vagal afferents and the gut-brain pathway — one year on Writing it up because I had to work it out twice and would rather nobody else did.
An honest uncertainty about Vagal afferents rather than a disguised assertion.
I do not know the answer and I have not been able to find one. What I have is the shape of the question, which may be worth more than my guess at the answer.
Biased agonism — where different ligands at the same receptor favour different downstream pathways — is a plausible explanation for differences between compounds in this class and is not a demonstrated one for any specific pair.
That holds for the case as described. Change the assumptions and it may not.
On the opening post — agreed on the reasoning, with one qualification.
Species differences in receptor pharmacology are substantial in this family, which is one reason rodent data has translated unevenly.
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About the Receptor biology category
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