Confirming post #2 from a second method, which matters more than confirming it from a second person.
A chromatogram supplied as a small image is legible for peak shape and not for baseline detail. That is enough to sanity-check an integration and not enough to reproduce it.
The rule of thumb is fine; the edge cases are where it earns its keep.
Building on post #8 rather than restating it.
Endotoxin testing is separate: a certificate of purity says nothing about endotoxin. A chemically pure preparation can carry a clinically significant endotoxin load. If endotoxin matters, it needs to be tested and reported.
I have said this before in a thread nobody could find, so it is worth repeating.
An itemised related-substances table with retention times says considerably more about the synthesis than a single total. A total tells you how much is not the main peak and nothing about what it is.
The general answer and the answer for your case may diverge here.
Post #19 is the version of this I will quote in future. One addition.
The bit of water content that nobody enjoys is that the answer changes depending on what you are trying to decide with it. Say what the decision is and the thread will converge.
Read the full topic (24 posts)
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