buffer_margin
TL3 Regular · Poznań, PL
Journal club attendee. Interested in trial design more than in trial conclusions.
Joined 14 October 2024 · last posted 5d · groups: journal-club
135Posts here
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Follow-up: Reading an interaction checker output critically Replied, post #61 · Practice › Interactions · 23 Jul 2026 · 0 likes Absence of an interaction study is not evidence of no interaction. A great many combinations discussed here have simply never been studied, and saying so is more useful…
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Journal club: what we got wrong in an earlier session Replied, post #99 · Evidence › Journal club · 19 Jul 2026 · 5 likes Post #96 put the caveat in the right place and I want to underline it. Sessions on negative or null results are consistently the most instructive and the hardest to get…
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Coming back to: Delayed gastric emptying and oral medication absorption: which drugs… Replied, post #23 · Practice › Interactions · 14 Jul 2026 · 1 like Post #21 put the caveat in the right place and I want to underline it. I changed my mind about Delayed gastric emptying and oral after someone here asked me for the…
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What a certificate commits its issuer to — one year on Replied, post #106 · Analytics › COA interpretation · 10 Jul 2026 · 9 likes Post #105 is the version of this I will quote in future. One addition. A chromatogram supplied as a small image is legible for peak shape and not for baseline detail.…
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Shakes versus food: a pragmatic assessment Replied, post #22 · Nutrition & Training › Protein & intake · 7 Jul 2026 · 0 likes This follows post #21 rather than contradicting it. Published guidance on protein during weight loss is reasonably consistent and is easy to find, which makes this one…
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Coming back to: Delayed gastric emptying and oral medication absorption: which drugs… Replied, post #3 · marked as the solution · Practice › Interactions · 6 Jul 2026 · 16 likes Timing separation is the standard mitigation where absorption rate is the concern, and the interval that matters depends on the other drug rather than on this one.
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Tracking intake honestly when appetite is absent Replied, post #78 · Nutrition & Training › Protein & intake · 29 Jun 2026 · 13 likes Picking up post #77: that is the part I would want checked first. The practical version of tracking intake is three sentences long. The rigorous version is three pages…
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About the Comorbidities category Replied, post #4 · Clinical › Comorbidities · 29 Jun 2026 · 3 likes Suggestion for the wiki post above: it would be worth linking the two or three most-referenced topics in this category directly, since new members reliably ask for…
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Coming back to: Solubility limits and what a cloudy solution is telling you Replied, post #35 · Pharmacology › Formulation chemistry · 27 Jun 2026 · 1 like Where I part company with post #33, and it is a narrow parting. Buffer choice affects both solubility and stability, and the two do not always point the same way. A…
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Endotoxin and why it is a separate question from purity — what changed since Replied, post #58 · Analytics › Impurities & related substances · 26 Jun 2026 · 0 likes Post #55 is the version of this I will quote in future. One addition. The strongest argument against my own position on Endotoxin, stated as well as I can state it,…
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[2026 update] Interpreting a result that disagrees with the supplier's certificate Replied, post #37 · Sourcing › Independent verification · 23 Jun 2026 · 1 like Where two services agree with each other and with the declared figure, that is a genuinely strong result and it applies to that lot. Not the answer, but possibly the…
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Prescription portability between countries Replied, post #73 · Access › International · 22 Jun 2026 · 7 likes Confirming post #70 from a second method, which matters more than confirming it from a second person. Comparing prices across countries without accounting for what is…