l.aguirre

TL2 · Catania

Contributes reviews on supplier material. Based in Catania.

Joined 2 October 2024 · last posted 1d · groups: newcomer-guides

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What a certificate commits its issuer to Replied, post #114 · Analytics › COA interpretation · 27 Jul 2026 · 29 likes An itemised related-substances table with retention times says considerably more about the synthesis than a single total. A total tells you how much is not the main…
Here for the analytics and not much else Replied, post #84 · Lounge › Introductions · 24 Jul 2026 · 26 likes Helpful, and short, which on this subject is harder than long.
[2026 update] Interpreting a result that disagrees with the supplier's certificate Replied, post #116 · Sourcing › Independent verification · 23 Jul 2026 · 12 likes The lot identifier has to match across vial, certificate and invoice for any of this to mean anything. It is the floor and it is worth checking every time. One of those…
Follow-up: How compounding permissions changed when supply normalised Replied, post #45 · Sourcing › Regulatory · 20 Jul 2026 · 11 likes Saving this. It is the version I will quote when the question comes round again.
About the Mass spectrometry category Replied, post #8 · Analytics › Mass spectrometry · 16 Jul 2026 · 16 likes Taking post #7 at face value and following it one step further. Sample preparation for mass spectrometry can itself introduce modifications, particularly oxidation. A…
Comparing my trajectory with the trial curves, carefully — a second dataset Replied, post #75 · Outcomes › Progress reports · 14 Jul 2026 · 7 likes Self-reported intake is optimistic in a consistent direction, and saying so in your own report is more credible than not. Happy to expand any of that if it is the…
Coming back to: A community side-effect dataset, with its response rate and biases Replied, post #94 · Data & Tools › Datasets · 11 Jul 2026 · 0 likes On community side-effect dataset the community has more anecdote than the confidence in this thread implies, and I include my own contribution in that.
Journal club: STEP 8 and the fairness of the comparator dose — a second dataset Replied, post #19 · Evidence › Journal club · 6 Jul 2026 · 0 likes Where I would push back on the STEP 8 consensus is the confidence, not the direction. The direction looks right. The confidence is borrowed.
Why a glucagon receptor agonist in a weight-loss compound is not a contradiction Replied, post #20 · Compounds › Retatrutide · 1 Jul 2026 · 7 likes Post #18 put the caveat in the right place and I want to underline it. Renal and cardiovascular outcome data does not exist for this compound. Absence of a reported…
Journal club: indirect comparison between two programmes, defended and attacked Replied, post #103 · Evidence › Journal club · 1 Jul 2026 · 0 likes SURPASS-2 (N Engl J Med 2021): Direct comparison of tirzepatide with semaglutide 1.0 mg. The 1.0 mg dose is not the highest available, which is the central and…
Journal club: SUSTAIN 6 and its retinopathy signal Started this topic · Evidence › Journal club · 26 Jun 2026 · 0 likes On the subject in the title: Journal club: SUSTAIN 6 and its retinopathy signal Working notes rather than a conclusion. Reading SUSTAIN 6 ( N Engl J Med , 2016) for the…
Reconstituting a multi-strength kit without mixing yourself up — what changed since Replied, post #32 · Practice › Reconstitution · 25 Jun 2026 · 0 likes Preservative effectiveness is tested against a defined microbial challenge under defined conditions. It is not a licence to treat an entered vial as sterile…