n.krastev

TL2 · Cork

Contributes reviews on supplier material. Based in Cork.

Joined 24 June 2025 · last posted 23h

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Why a pen's dose steps are fixed and what that costs you Replied, post #5 · Devices › Pens & autoinjectors · 27 Jul 2026 · 0 likes A pen delivers a fixed or dialled dose from a cartridge and is a metering device rather than simply a covered syringe. That is why dose changes are constrained to…
Reading order for a first week here, and what to skip until later — what changed since Replied, post #45 · Start Here › Welcome · 15 Jul 2026 · 13 likes On the reading order question specifically: start with the how-to-ask materials in this category, then read the one to three subcategories where your main questions…
Second pass at: When your prescriber and the evidence disagree Replied, post #45 · Clinical › Prescriber conversations · 4 Jul 2026 · 8 likes I read post #43 twice before replying, because I had assumed the opposite. Prescriber came up in a thread eighteen months ago and was answered well. I cannot find it,…
Peak-to-trough ratio at steady state for a weekly agent — the long version Replied, post #40 · Pharmacology › Pharmacokinetics · 3 Jul 2026 · 3 likes Post #38 put the caveat in the right place and I want to underline it. Metabolism for peptide drugs is proteolytic rather than hepatic in the usual sense, which is why…
Second pass at: Leak-back after withdrawal and whether you lost a meaningful dose Replied, post #21 · Practice › Administration · 23 Jun 2026 · 6 likes Post #19 put the caveat in the right place and I want to underline it. Air in the syringe is a much smaller problem subcutaneously than the anxiety about it suggests,…
Specificity, linearity, accuracy, precision, range, robustness — with real criteria Replied, post #29 · Analytics › Method validation · 12 Jun 2026 · 0 likes An independent laboratory's method being different from the supplier's is not a discrepancy. It becomes one only when the results differ by more than both methods'…
Reading a trial's population section before its results Replied, post #101 · Evidence › Trials · 8 Jun 2026 · 13 likes Entry criteria, run-in periods and the self-selection of people willing to enter a multi-year trial all narrow the population. That is how internal validity is bought…
Journal club: STEP 1 and the treatment-policy estimand — does this still hold? Replied, post #30 · Evidence › Journal club · 30 May 2026 · 15 likes STEP 1: I have looked for the primary source twice and failed twice. Either it does not exist or it is somewhere I do not know to look, and I would like to know which.
The anatomy of a question that gets answered within an hour Replied, post #54 · Start Here › How to Ask · 23 May 2026 · 0 likes I had written a reply contradicting post #50 and deleted it. Here is what survived. Post the arithmetic you already did. Half the questions here are answered by someone…
Revisiting: Drawing up with one needle and injecting with another Replied, post #55 · Practice › Administration · 6 Apr 2026 · 5 likes Leave real distance between consecutive sites rather than moving a centimetre. Repeatedly injecting one area changes the local tissue over time and eventually changes…
The "under review" status pill and when a moderator applies it Replied, post #11 · Evidence › Preprints · 7 Mar 2026 · 12 likes Reading a preprint properly means doing some of the reviewer's job: methods first, then whether the analysis matches the plan, then the conclusion. Noting that the…
Pregnancy and pregnancy planning: contraindication and washout Replied, post #58 · Clinical › Special populations · 1 Mar 2026 · 1 like Pregnancy and breastfeeding are the clearest cases where the answer is that the trials excluded them and the labelling reflects that exclusion. Adding this to the…