t.vasquez
TL4 Moderator Moderator · Evidence · Barcelona, ES
Moderate the evidence categories and chair most journal club sessions. Trained in clinical epidemiology. I care more about whether a study could have answered the question than whether I like the answer.
Joined 18 May 2024 · last posted 11h · groups: staff, moderators, journal-club, trust-level-4
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Revisiting: The best-written scientific paper you have read Replied, post #121 · Lounge › Off topic · 27 Jul 2026 · 0 likes Thank you — that answers what I came here to find out.
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The anatomy of a question that gets answered within an hour Replied, post #123 · Start Here › How to Ask · 23 Jul 2026 · 1 like A photograph of a vial is rarely useful and a photograph of a document usually is. Redact the identifiers before you post either.
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A site rotation scheme that is easy enough to actually follow Replied, post #122 · Practice › Administration · 23 Jul 2026 · 0 likes Post #119 is right about the mechanism and I think understates the practical bit. Practical note on site rotation scheme: write down what you expect before you look.…
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What is genuinely unknown about long-term amylin agonism Replied, post #65 · Compounds › Cagrilintide & amylin analogues · 21 Jul 2026 · 0 likes Native amylin has awkward physical properties — it aggregates readily, which is why a stable analogue is a pharmaceutical achievement rather than a formulation detail.…
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Reading a home test result without over-claiming Replied, post #128 · Analytics › Home & field testing · 21 Jul 2026 · 26 likes That is clearer than the version I had in my head. Thank you.
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[2026 update] Detection wavelength and why 214 nm and 280 nm disagree Replied, post #53 · Analytics › HPLC & UHPLC · 20 Jul 2026 · 0 likes If two laboratories disagree by more than two or three percentage points, work through method, integration, sample handling, whether it was the same lot and the same…
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Immortal time bias in a claims-database study — one year on Replied, post #29 · Evidence › Study critique · 18 Jul 2026 · 11 likes Attrition is the failure mode most likely to invalidate a result and the least likely to be discussed. Differential attrition between arms is the specific thing to look…
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Reading a rodent study on a secretagogue without over-extrapolating — the long version Replied, post #44 · Compounds › Secretagogues & GH axis · 16 Jul 2026 · 4 likes Practical answer on Reading a rodent study, since the theoretical one is upthread: do the simplest check first, write down the result, and only then decide whether the…
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Named, unnamed and unspecified impurities as regulatory categories — the long version Replied, post #79 · Analytics › Impurities & related substances · 15 Jul 2026 · 4 likes Aggregates may be a multiple of the monomer mass and may not elute at all under a standard method. What does not come off the column does not appear in the area…
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Revisiting: Why the absence of controlled human data on BPC-157 matters more than people… Replied, post #28 · Compounds › Repair & healing peptides · 13 Jul 2026 · 4 likes Taking post #25 at face value and following it one step further. Analytical identity of BPC-157: a 15-residue peptide with an unambiguous mass (≈1419.5 Da). Identity…
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A structured critique template this community uses — a second dataset Replied, post #31 · Evidence › Study critique · 7 Jul 2026 · 1 like Blinding, duration and comparator choice trade against each other. Improving one usually costs another, and a critique that ignores the trade is incomplete.
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Alcohol: what is documented and what is folklore Replied, post #97 · Practice › Interactions · 7 Jul 2026 · 31 likes Practical note on alcohol: write down what you expect before you look. The number of times I have found what I went looking for is higher than chance would allow.