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Evidence · Study critique · continued

A structured critique template this community uses — a second dataset posts 31–52

This is a continuation of a long topic, addressed by post number rather than by page. Start at post 1 · go to the accepted answer.

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t.vasquezTL4 Moderator7 Jul 2026 · edited#31

Blinding, duration and comparator choice trade against each other. Improving one usually costs another, and a critique that ignores the trade is incomplete.

1 like 20d
VB
va.baptistaTL28 Jul 2026#32
Ziegler, post #13: On post #11 — agreed on the reasoning, with one qualification. Where a critique changes your position, saying so in the thread is worth more than being right, and it is the thing this subcategory does better than most places. Go to post

Where a critique rests on a subgroup, check whether the interaction was tested. A difference between subgroups that is not statistically supported is not a difference.

This has been discussed before and I could not find the thread, so, again.

0 likes in reply to #13 19d
SC
so.cardosoTL29 Jul 2026#33

Post #29 put the caveat in the right place and I want to underline it.

A note on how structured critique template gets discussed rather than on structured critique template itself: the confident posts get the replies and the careful ones get ignored, and the careful ones have been right more often.

24 likes 18d
SD
s.dziedzicTL210 Jul 2026#34

Structured critique template came up in a thread eighteen months ago and was answered well. I cannot find it, which is itself the problem, so here is the reconstruction.

11 likes 17d
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system_suitabilityTL3Analytical chemist11 Jul 2026 · edited#35

Agreed, and I will stop repeating the version of this I had been repeating.

3 likes 16d
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h.delgadoTL212 Jul 2026#36
diluent_watch, post #11: Hold a trial to the standard something could actually have met. A criticism that no achievable design could have answered is a criticism of the field rather than of the paper. The strength of my opinion here exceeds the strength of my evidence. Go to post

Generalisability: do the inclusion/exclusion criteria narrow the population so much that results do not apply to real people asking about it? This is a fair criticism but requires specificity about which real people and why the difference matters.

0 likes in reply to #11 15d
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compounding_ruthTL413 Jul 2026#37
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j.asanteTL214 Jul 2026#38

Taking post #36 at face value and following it one step further.

Reporting rather than recommending, on structured critique template. What happened is above. Whether it should have is a different question and not one I am qualified to answer.

17 likes 14d
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f.demirTL2Regular15 Jul 2026#39
g.verhoeven, post #16: Confirming post #15 from a second method, which matters more than confirming it from a second person. Multiple comparisons: if a paper reports many outcomes, the chance of a spurious association by random chance is real. Pre-specification of primary outcomes matters and secondary analyses are weaker evidence. Go to post

Post #38 describes the usual case. This is about the unusual one.

Offering a way to settle structured critique template rather than another opinion about it. Two measurements, taken the same way, a fortnight apart. If the difference is within the noise, the question was not answerable at this precision.

0 likes in reply to #16 13d
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s.balogunTL216 Jul 2026#40

Attrition is the failure mode most likely to invalidate a result and the least likely to be discussed. Differential attrition between arms is the specific thing to look for.

That is a description of practice, not a recommendation of it.

25 likes 12d
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chromatogramTL4Analytical chemist17 Jul 2026 · edited#41

Two things can be true about structured critique template at once: the mechanism is plausible and the evidence for the size of the effect is thin. Most of the argument here is people defending the first against attacks on the second.

3 likes 11d
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t.dumitruTL218 Jul 2026#42

Answering the question post #40 raises rather than the one it answers.

The strongest critiques cite the section they rely on. A critique without a page reference is an impression, however well informed.

11 likes 10d
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s.leclercTL4 Moderator19 Jul 2026#43

Post #42 is the version of this I will quote in future. One addition.

Adding the boring version of structured critique template, because the interesting version keeps getting posted and the boring one is usually right.

Check the ordinary explanations, in order, and stop when one of them accounts for what you are seeing. Most of the time the second one does.

31 likes 9d
AW
a.wikstromTL220 Jul 2026#44
s.balogun, post #40: Attrition is the failure mode most likely to invalidate a result and the least likely to be discussed. Differential attrition between arms is the specific thing to look for. That is a description of practice, not a recommendation of it. Go to post

The confident answers on structured critique template and the well-sourced answers are not the same answers, which is the most useful thing I have learned reading this category.

0 likes in reply to #40 8d
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TL4_HalvorsenTL4Leader · Journal club21 Jul 2026#45

Adding the measurement that post #42 says would settle it.

A run-in period that excludes non-responders before randomisation changes what the trial is estimating. It is legitimate design and it must be stated in any summary.

I have kept the units in throughout, for the obvious reason.

1 like 7d
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h.lindqvistTL222 Jul 2026#46

Post #44 describes the usual case. This is about the unusual one.

Worth separating structured critique template as a question about the compound from structured critique template as a question about the documentation. They get answered by different people and only one of them is answerable here.

6 likes 6d
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endo_fellow_rkTL3Endocrinology fellow23 Jul 2026#47

Generalisability and validity are separate axes. A trial can be internally impeccable and still tell you nothing about the person asking.

Genuinely open to being wrong about this one.

23 likes 5d
JV
j.vogelTL224 Jul 2026#48
policy_reader, post #1: On the subject in the title: A structured critique template this community uses — a second dataset Working notes rather than a conclusion. Posting a small dataset on structured critique template. It is mine, it is uncontrolled, and the method is stated so it can be discounted appropriately. What I would like is not agreement but a… Go to post

The question underneath structured critique template is usually "how would I tell?" rather than "what is true?", and that one has a method attached to it.

Write down what you would expect to see under each hypothesis before you collect anything. If they predict the same observation, collecting it will not help.

0 likes in reply to #1 4d
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weekly_pinTL2Regular25 Jul 2026#49
TL4_Halvorsen, post #45: Adding the measurement that post #42 says would settle it. A run-in period that excludes non-responders before randomisation changes what the trial is estimating. It is legitimate design and it must be stated in any summary. I have kept the units in throughout, for the obvious reason. Go to post

Picking up post #46: that is the part I would want checked first.

I would put moderate confidence on the mainstream reading of structured critique template and no more. That is not scepticism for its own sake; it is where the sourcing actually stops.

0 likes in reply to #45 3d
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a.delgadoTL225 Jul 2026 · edited#50

Surrogate endpoints are not automatically bad and their validity is compound-specific and population-specific. The question is whether this surrogate has been validated for this use.

On balance I think that is right, and I would not bet much on it.

3 likes 2d
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y.rahimiTL226 Jul 2026#51

Post #47 describes the usual case. This is about the unusual one.

A critique should end with what would change your mind. Without that it is a position rather than an argument.

1 like 2d
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preregisteredTL3Research methods27 Jul 2026#52

The practical version of structured critique template is three sentences long. The rigorous version is three pages and reaches the same conclusion with the conditions attached.

0 likes 15h

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