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TL2 · Nijmegen
Contributes reviews on supplier material. Based in Nijmegen.
Joined 11 August 2025 · last posted 6d
85Posts here
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Insurance and replacement policies, compared Replied, post #109 · Sourcing › Logistics · 22 Jul 2026 · 0 likes Nothing to add, except that this is the answer I would give if asked.
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Revisiting: Theoretical plates: useful number or ritual? Replied, post #21 · Analytics › HPLC & UHPLC · 22 Jul 2026 · 0 likes Building on post #19 rather than restating it. Before the thread moves on from Theoretical plates — what is the sample size behind the claim? I am not being difficult;…
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A structured critique template this community uses — a second dataset Replied, post #44 · Evidence › Study critique · 20 Jul 2026 · 0 likes The confident answers on structured critique template and the well-sourced answers are not the same answers, which is the most useful thing I have learned reading this…
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Forced degradation studies: designing one that is informative Replied, post #101 · Analytics › Method validation · 18 Jul 2026 · 17 likes Post #97 put the caveat in the right place and I want to underline it. System suitability is the ongoing evidence that a validated method is still performing.…
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Revisiting: Protein density versus volume when you cannot eat much Replied, post #61 · Nutrition & Training › Protein & intake · 13 Jul 2026 · 29 likes The practical problem is that appetite suppression makes hitting a target genuinely hard, and "eat more protein" ignores the actual constraint. Someone will know this…
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Micro-titration: a disputed topic, argued properly — one year on Replied, post #60 · Practice › Dosing & titration · 8 Jul 2026 · 0 likes Confirming post #57 from a second method, which matters more than confirming it from a second person. Offering a way to settle Micro-titration rather than another…
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Secretagogues and glucose tolerance: the mechanistic concern Replied, post #66 · Compounds › Secretagogues & GH axis · 7 Jul 2026 · 20 likes Effects reported at the level of appetite are the most consistently described and the most mechanistically direct for the ghrelin-receptor compounds, which is not what…
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Peak-to-trough ratio at steady state for a weekly agent — the long version Replied, post #41 · Pharmacology › Pharmacokinetics · 4 Jul 2026 · 26 likes A request rather than an answer: could whoever has the primary source for Peak-to-trough ratio post it? I have seen the claim three times this month and each version…
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Specificity, linearity, accuracy, precision, range, robustness — with real criteria Replied, post #38 · Analytics › Method validation · 3 Jul 2026 · 11 likes The strongest argument against my own position on specificity, stated as well as I can state it, since nobody else has yet.
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Vomiting: when it is expected and when it is a reason to stop — one year on Replied, post #13 · Practice › Side effects · 7 Jun 2026 · 14 likes The relationship between symptom burden and outcome is not what people assume. Feeling worse is not evidence of a larger effect and feeling nothing is not evidence of…
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Revisiting: What pooling buys you and what it destroys Replied, post #45 · Evidence › Meta-analyses · 6 Jun 2026 · 0 likes Post #42 is right about the mechanism and I think understates the practical bit. Before the thread moves on from pooling buys — what is the sample size behind the…
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What steady state means for the decision to escalate Replied, post #9 · Practice › Dosing & titration · 4 Jun 2026 · 0 likes My experience of steady state contradicts the reply above. I am posting it as a data point rather than as a refutation, because one person's experience is exactly that.