taper_file
TL3 Regular · Sheffield, UK
Laboratory background. Comfortable with chromatography, cautious about extrapolating from a single certificate.
Joined 10 September 2024 · last posted 10h · groups: analytical-chemists
127Posts here
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Deletion sequences: expected mass shifts by residue — the long version Replied, post #26 · Analytics › Impurities & related substances · 27 Jul 2026 · 5 likes Aggregates: multiples of the monomer mass. May not elute at all under a standard reversed-phase method. A species that does not come off the column does not appear in…
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Coming back to: Preparing for an appointment: one page, three questions Replied, post #44 · Clinical › Prescriber conversations · 24 Jul 2026 · 0 likes That is a fair summary of where the discussion has got to.
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Why the Start Here categories exist, and what they are not for Replied, post #33 · Start Here › Welcome · 24 Jul 2026 · 5 likes Speaking only to Start as I have actually seen it, rather than as it is usually described: the effect is real, it is smaller than the thread suggests, and the variance…
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eGFR fluctuation and the creatinine denominator problem — the long version Replied, post #25 · Clinical › Bloodwork · 22 Jul 2026 · 4 likes A trend needs at least three points to be a trend. Two points are a line and a line through noise is still a line. The interesting part of this is the exception, and I…
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Revisiting: What pooling buys you and what it destroys Replied, post #100 · Evidence › Meta-analyses · 21 Jul 2026 · 6 likes Post #99 is right about the mechanism and I think understates the practical bit. Pooling buys is one of those subjects where the general answer and the answer for a…
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Tracking intake honestly when appetite is absent Replied, post #106 · Nutrition & Training › Protein & intake · 20 Jul 2026 · 14 likes Liquid sources are tolerated better than solid ones by many people here, and that is a practical observation rather than a nutritional principle. This is the sort of…
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Coming back to: Delayed gastric emptying and oral medication absorption: which drugs… Replied, post #42 · Practice › Interactions · 19 Jul 2026 · 4 likes Post #39 is right about the mechanism and I think understates the practical bit. Timing separation is the standard mitigation where absorption rate is the concern, and…
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Coming back to: Preparing for an appointment: one page, three questions Started this topic · Clinical › Prescriber conversations · 15 Jul 2026 · 7 likes Preparing for an appointment: one page, three questions — setting out what I have, and where I think it stops being reliable. A question about how to describe something…
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Second pass at: The storage lookup and where its data comes from Replied, post #43 · Data & Tools › Calculators · 9 Jul 2026 · 1 like I keep a log for storage lookup specifically because my memory of it turned out to be systematically wrong in one direction. Six weeks of notes cost nothing and settled…
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Reading order for a first week here, and what to skip until later — what changed since Replied, post #23 · Start Here › Welcome · 8 Jul 2026 · 1 like Adding what did not work for me on Reading order, since the failures never get written up and they are half the useful information.
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Second pass at: Metformin co-administration and additive GI effects Replied, post #140 · Practice › Interactions · 5 Jul 2026 · 0 likes Coming back to post #138, because the follow-up matters more than the original answer. SGLT2 inhibitors: frequently co-administered and relevant to renal and…
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Trust level 3 requirements: a clarification — does this still hold? Replied, post #75 · Meta › Announcements · 2 Jul 2026 · 4 likes Filing a mild objection to the consensus on Trust level 3 requirements. Mild because I might be wrong; an objection because nobody has addressed the case that does not…
Maintains 4 documents
- Liraglutide — referenceReview due 8 Mar 2027
- Oral semaglutide — referenceReview due 24 Jan 2027
- Janoshik Analytical — what its reports establishReview due 22 Aug 2026
- Medutest — what its reports establishReview due 28 Feb 2027