Anaesthesia and elective surgery: the aspiration question — does this still hold?

Anaesthesia and elective surgery: the aspiration question — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below.

Asking about Anaesthesia and elective surgery directly, because I have read four threads on it and each answered a slightly different question.

The version I want answered is the narrow one: given the method stated below, is the result within what anyone else has seen? I am not asking what it means yet.

Method, numbers and the two assumptions I am aware of making are below. If the assumptions are wrong that is more useful to me than agreement.

A supplement is a drug for interaction purposes, and the fact that it is sold without a prescription tells you nothing about whether it interacts. The paperwork is usually worse rather than better.

The variance between people here is larger than the effect being discussed.

I read the opening post twice before replying, because I had assumed the opposite.

The thing about Anaesthesia and elective surgery that took me longest to accept is that a plausible mechanism is not evidence of an effect. It is a reason to look, not a result.

Anticoagulant questions come up regularly and are the clearest case for professional advice rather than discussion, because the consequence of being wrong is not gradual.

That matches what I was told, which is not the same as knowing it.

Nothing here is medical advice and an interaction question is one where the cost of a wrong forum answer is genuinely high. Ask the prescriber or the pharmacist.

A weak preference rather than a position.

Coming back to post #5, because the follow-up matters more than the original answer.

Two questions I would want answered before drawing anything from the Anaesthesia and elective surgery data above: how were the cases selected, and what happened to the ones that dropped out.

Understood, and I withdraw the assumption I opened with.

On post #5 — agreed on the reasoning, with one qualification.

The number people quote for Anaesthesia and elective surgery is a central estimate presented without its interval, and the interval is wide enough that the estimate is nearly uninformative on its own.

Picking up post #9: that is the part I would want checked first.

The most defensible general position in this subcategory: identify the plausible mechanism, check whether it has been studied, and where it has not, say that rather than filling the gap.

Nothing to add on the substance. Thank you for taking the question at face value.

What I can speak to on Anaesthesia and elective surgery is narrow, so I will keep it narrow rather than generalising from it. Beyond that boundary I do not know.

Insulin and sulfonylureas are the interaction that the labelling in this class flags most explicitly, because the risk is additive glucose lowering. That is a prescribing question and not a forum question.

I have kept the units in throughout, for the obvious reason.

Post #12 and I disagree about the size of the effect, not about the direction.

The most useful reply I ever got about Anaesthesia and elective surgery was a request to state my units. It sounds like pedantry and it has saved me twice.