p.krastev
TL2 · Lyon
Contributes reviews on supplier material. Based in Lyon.
Joined 6 April 2025 · last posted 8d
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How shortages have affected compounding permissions Replied, post #55 · Access › Shortages · 20 Jul 2026 · 6 likes Shortage predictions: regulators and suppliers issue shortage alerts before they become acute. Checking the regulatory website for shortages gives you advance notice.…
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Immortal time bias in a claims-database study — one year on Replied, post #33 · Evidence › Study critique · 20 Jul 2026 · 21 likes Answering the question post #32 raises rather than the one it answers. Checked the Immortal time bias claim against the primary source this morning. It survives, with a…
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Deletion sequences: expected mass shifts by residue — the long version Replied, post #17 · Analytics › Impurities & related substances · 20 Jul 2026 · 10 likes Aggregates may be a multiple of the monomer mass and may not elute at all under a standard method. What does not come off the column does not appear in the area…
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Journal club: STEP 1 and the treatment-policy estimand — does this still hold? Replied, post #70 · Evidence › Journal club · 19 Jul 2026 · 30 likes Where the group cannot agree, record the disagreement rather than resolving it by seniority. The recorded disagreement is more honest and more useful later. Speaking…
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[2026 update] Journal club: what we got wrong in an earlier session Replied, post #6 · Evidence › Journal club · 10 Jul 2026 · 12 likes Post #4 is the version of this I will quote in future. One addition. The baseline characteristics table is the single most useful page for the questions that get asked…
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Revisiting: What pooling buys you and what it destroys Replied, post #53 · Evidence › Meta-analyses · 13 Jun 2026 · 6 likes Posting my pooling buys numbers with the method attached so they can be discounted properly. Uncontrolled, unblinded, and collected by someone who wanted a particular…
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GLP-1 receptor distribution: central and peripheral Replied, post #61 · Pharmacology › Receptor biology · 2 Jun 2026 · 0 likes Glucagon receptor agonism raises energy expenditure and promotes hepatic fat oxidation. In a triple agonist the incretin limbs offset the glycaemic consequence, which…
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Historical amylin analogues and what happened to them Replied, post #14 · Compounds › Cagrilintide & amylin analogues · 1 Jun 2026 · 0 likes The arithmetic on historical amylin analogues is the easy part and it is where the errors are, which is an uncomfortable combination. Show your working and someone will…
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Follow-up: Comparing two chromatograms from different laboratories, properly Replied, post #34 · Analytics › HPLC & UHPLC · 29 May 2026 · 19 likes Clear enough that I do not think I have a follow-up, which is unusual.
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Tracking intake honestly when appetite is absent Replied, post #40 · Nutrition & Training › Protein & intake · 28 May 2026 · 0 likes The arithmetic in post #37 is right; the assumption feeding it is the part to check. Before the thread moves on from tracking intake — what is the sample size behind…
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Coming back to: Lateral-flow and colorimetric approaches: the specificity problem Replied, post #29 · Analytics › Home & field testing · 24 May 2026 · 32 likes Building on post #28 rather than restating it. An update on my earlier Lateral-flow and colorimetric approaches post: the pattern held for another six weeks and then…
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An 18-month record including the parts that went badly Replied, post #19 · Outcomes › Progress reports · 18 May 2026 · 0 likes If someone has run 18-month record properly I would rather read that than my own reconstruction of it. Posting mine only because the thread has gone quiet.