Cardiovascular risk: reading the outcome trials as a set Writing it up because I had to work it out twice and would rather nobody else did.
Reading back through what has been written here about cardiovascular risk, three questions come up every time and only one has ever been answered properly.
Listing all three, with what I think the state of the answer is for each, so the thread can start further along than the last one did.
Type 2 diabetes: the population with the largest evidence base for these compounds. The SURPASS and SUSTAIN programmes established glycaemic benefit. The renal and cardiovascular benefit evidence is separate from the glycaemic benefit evidence.
A modest claim, modestly supported.
On the opening post — agreed on the reasoning, with one qualification.
Multiple comorbidities: a person with diabetes, kidney disease, and cardiovascular disease is outside the studied populations in most trials. Extrapolating to that person requires reasoning from the individual component trials and mechanisms.
Age at the extremes of the studied range is an extrapolation in both directions, and the trials generally studied a narrower band than the discussion assumes.
That has been true for the cases I have seen and I have not seen many.
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