Post #3 is right about the mechanism and I think understates the practical bit.
Filing a mild objection to the consensus on column chemistry choices. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit.
Practical experience of column chemistry choices, offered as one case with the conditions stated, not as a general finding. Conditions first, because they are what make it interpretable.
Answering the question post #28 raises rather than the one it answers.
The confident answers on column chemistry choices and the well-sourced answers are not the same answers, which is the most useful thing I have learned reading this category.
Answering the column chemistry choices question as asked, then the question I think is meant. As asked: yes, with the qualification below. As meant: it depends on how the first measurement was taken.
Taking post #41 at face value and following it one step further.
Counterpoint on column chemistry choices, offered without confidence: the same observation is consistent with a much duller explanation, and nobody has ruled the dull one out.
Read the full topic (44 posts)
| Topic | Participants | Replies | Views | Activity |
|---|---|---|---|---|
|
Area percent versus weight percent: the confusion that causes most arguments
Posting this under the heading it deserves: Area percent versus weight percent: the confusion that causes most arguments Everything below is what sits behind that. Proposing that area percent versus weight…
|
+10 | 14 | 2.1k | 2mo |
|
Carryover and the ghost peak from last week's standard — what changed since
Carryover and the ghost peak from last week's standard — what changed since Writing it up because I had to work it out twice and would rather nobody else did. What changes if the standard account of Carryover…
|
+98 | 114 | 37k | 22d |
|
[2026 update] Area percent versus weight percent: the confusion that causes most arguments
On the subject in the title: Area percent versus weight percent: the confusion that causes most arguments Working notes rather than a conclusion. Proposing that Area percent versus weight percent deserves a…
|
+65 | 70 | 1.1k | 16d |
|
Comparing two chromatograms from different laboratories, properly
Posting this under the heading it deserves: Comparing two chromatograms from different laboratories, properly Everything below is what sits behind that. I would like to understand what this number means…
|
+35 | 40 | 22k | 7mo |
|
Detection wavelength and why 214 nm and 280 nm disagree
On the subject in the title: Detection wavelength and why 214 nm and 280 nm disagree Working notes rather than a conclusion. I would like to disagree carefully with the settled view on detection wavelength,…
|
+78 | 84 | 1.7k | 8mo |
| Topic | Participants | Replies | Views | Activity |
|---|---|---|---|---|
|
Why one laboratory's 98.4% and another's 96.1% may not contradict — one year on
Asking directly, because I could not find a straight answer: Why one laboratory's 98.4% and another's 96.1% may not contradict — one year on Posting the method first, because I know what the first three…
|
+10 | 14 | 13k | 5mo |
|
Coming back to: Where the integrator drew the baseline, and how much it moved the number
On the subject in the title: Where the integrator drew the baseline, and how much it moved the number Working notes rather than a conclusion. Posting the method first, because I know what the first three…
|
+20 | 24 | 2.7k | 10mo |
|
Shoulders, tangent skims, and defensible integration — the long version
Shoulders, tangent skims, and defensible integration — the long version Writing it up because I had to work it out twice and would rather nobody else did. Setting out an integration problem with the actual…
|
+16 | 20 | 27k | 3mo |
|
Area percent versus weight percent: the confusion that causes most arguments — what changed since
Area percent versus weight percent: the confusion that causes most arguments — what changed since Writing it up because I had to work it out twice and would rather nobody else did. What changes if the…
|
+30 | 34 | 40k | 13mo |
|
Named, unnamed and unspecified impurities as regulatory categories — the long version
Named, unnamed and unspecified impurities as regulatory categories — the long version — setting out what I have, and where I think it stops being reliable. Two reports on the same lot, and I would like help…
|
+112 | 120 | 7.6k | 5h |