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Coming back to: Official shortage notices and what they authorise

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Solved by o.vogel in post #7
The version of Official shortage notices that circulates here is a simplification of a simplification. It is not wrong, but it has lost the conditions under which it holds, and those conditions are where the interesting cases live.

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DO
d.oyelaranTL3Pharmacist3 Feb 2025#1

Official shortage notices and what they authorise — setting out what I have, and where I think it stops being reliable.

Official shortage notices — I have the observation and I do not trust my interpretation of it, so I am posting the observation and holding the interpretation back.

Numbers, method and the conditions under which they were collected are below. Interpret them however they warrant.

13 likes 18mo
FF
f.fenwickTL3Regular4 Feb 2025 · edited#2

The published shortage register maintained by the national regulator is the authoritative source here, and it is updated far more often than any thread.

I have no interest in any supplier named above.

1 like 18mo
AP
ar.petrovTL25 Feb 2025#3
f.fenwick, post #2: The published shortage register maintained by the national regulator is the authoritative source here, and it is updated far more often than any thread. I have no interest in any supplier named above. Go to post

Dose hold versus tapering: if a temporary shortage forces a gap, holding your dose and resuming when supply returns is different from gradually tapering. The two are different decisions.

0 likes in reply to #2 18mo
RS
r.scholtenTL2Member6 Feb 2025#4
f.fenwick, post #2: The published shortage register maintained by the national regulator is the authoritative source here, and it is updated far more often than any thread. I have no interest in any supplier named above. Go to post

This follows post #3 rather than contradicting it.

Shortage predictions: regulators and suppliers issue shortage alerts before they become acute. Checking the regulatory website for shortages gives you advance notice.

24 likes in reply to #2 18mo
RD
r.danquahTL26 Feb 2025#5

I read post #3 twice before replying, because I had assumed the opposite.

Compounding during shortages: some jurisdictions allow pharmacy compounding when a marketed product is in shortage. That permission is jurisdiction-specific and time-limited (usually for the duration of the shortage).

The rule of thumb is fine; the edge cases are where it earns its keep.

4 likes 18mo
RV
r.villalobosTL27 Feb 2025#6

Adding a note of thanks rather than an opinion. I did not know most of that.

0 likes 18mo
OV
o.vogelTL2 Solution8 Feb 2025#7

The version of Official shortage notices that circulates here is a simplification of a simplification. It is not wrong, but it has lost the conditions under which it holds, and those conditions are where the interesting cases live.

7 likes 18mo
MD
m.duarteTL28 Feb 2025#8
r.danquah, post #5: I read post #3 twice before replying, because I had assumed the opposite. Compounding during shortages: some jurisdictions allow pharmacy compounding when a marketed product is in shortage. That permission is jurisdiction-specific and time-limited (usually for the duration of the shortage). The rule of thumb is fine; the edge cases are… Go to post

Supply interruptions: official shortage notices are published by regulatory agencies. That is the correct primary source rather than pharmacy rumors or forum discussion.

17 likes in reply to #5 18mo
BN
bench_notesTL4 Moderator9 Feb 2025#9

Everything in post #7 holds. The case it does not cover is the one I have.

What I would want before treating Official shortage notices as settled: the method, the sample, and whether anyone tried to find the opposite result. Two of the three are usually missing.

1 like 18mo
KP
k.perrinTL210 Feb 2025#10

Narrowing post #7, because the general version has more than one answer.

Where a shortage forces a gap, the pharmacokinetics mean a missed week is a perturbation rather than a reset, which is worth knowing.

Posted with less confidence than the sentence structure implies.

0 likes 18mo
CC
c.correiaTL210 Feb 2025#11

This follows post #8 rather than contradicting it.

Worth separating Official shortage notices as a question about the compound from Official shortage notices as a question about the documentation. They get answered by different people and only one of them is answerable here.

0 likes 18mo
ME
me.eriksenTL211 Feb 2025#12

Shortages end and the notices are updated. Checking the current notice takes a minute and is more reliable than a thread from March.

1 like 18mo
ML
m.lindqvistTL211 Feb 2025#13
bench_notes, post #9: Everything in post #7 holds. The case it does not cover is the one I have. What I would want before treating Official shortage notices as settled: the method, the sample, and whether anyone tried to find the opposite result. Two of the three are usually missing. Go to post

Regional differences during a shortage are large, and a supply position in one country says nothing about another.

7 likes in reply to #9 17mo
RR
r.restrepoTL212 Feb 2025 · edited#14

Switching presentation or strength during a shortage is a prescribing decision rather than a substitution anybody should improvise.

Second-hand, so weight it accordingly.

18 likes 17mo
AW
a.westergaardTL3Regular13 Feb 2025#15

Stockpiling in response to a shortage worsens it, which is true and is a poor argument to make to somebody who has run out.

0 likes 17mo
MM
m.malinowskiTL213 Feb 2025#16

Shortage status determines what compounding is permitted in some jurisdictions, which links two questions that otherwise seem unrelated.

0 likes 17mo
JD
j.delacroixTL3Regular14 Feb 2025#17
r.restrepo, post #14: Switching presentation or strength during a shortage is a prescribing decision rather than a substitution anybody should improvise. Second-hand, so weight it accordingly. Go to post

Pharmacy-level availability varies enormously during a shortage, so two honest accounts from the same city can be opposite.

I have left out the parts I could not verify.

4 likes in reply to #14 17mo
SO
sa.okonkwoTL214 Feb 2025#18

Thank you — that answers what I came here to find out.

12 likes 17mo
OV
o.vukovicTL215 Feb 2025#19

A shortage of one presentation is not a shortage of all of them, and the published notices are specific about which.

It is worth checking rather than assuming, which costs nothing.

1 like 17mo
OO
orbitrap_olaTL3Mass spectrometrist15 Feb 2025#20
r.scholten, post #4: This follows post #3 rather than contradicting it. Shortage predictions: regulators and suppliers issue shortage alerts before they become acute. Checking the regulatory website for shortages gives you advance notice. Go to post

Manufacturer allocation decisions during a shortage are commercial and are rarely explained, which is frustrating and is not evidence of anything.

This has been discussed before and I could not find the thread, so, again.

7 likes in reply to #4 17mo
D
DOdendaalTL3Regular16 Feb 2025#21

On post #19 — agreed on the reasoning, with one qualification.

Managing an unplanned gap: if a shortage causes a gap in treatment, the questions are how long the gap will be and how that affects your condition. Discussing with your clinician is prudent if the gap is weeks or longer.

I would treat the number as indicative rather than as a measurement.

27 likes 17mo
DV
d.vestergaardTL216 Feb 2025#22

The most useful contribution is a link to the current official notice rather than an account of one pharmacy.

I have separated what I observed from what I concluded, which does not always happen.

13 likes 17mo
VT
vial_tableTL2Member17 Feb 2025#23

Planning around a known shortage window is easier than reacting to one, and the notices give advance warning more often than people expect.

2 likes 17mo
SS
s.salgadoTL217 Feb 2025#24
c.correia, post #11: This follows post #8 rather than contradicting it. Worth separating Official shortage notices as a question about the compound from Official shortage notices as a question about the documentation. They get answered by different people and only one of them is answerable here. Go to post

Post #23 is right about the mechanism and I think understates the practical bit.

On Official shortage notices I would separate what is worth knowing from what is worth acting on. The first list is long and the second is short, and conflating them is how threads get heated.

0 likes in reply to #11 17mo
AS
a.stephanopoulosTL3Regular18 Feb 2025#25

Same experience here, different supplier, so it is at least not unique to one of them.

0 likes 17mo
LC
l.cabreraTL218 Feb 2025#26

The most useful contribution is a link to the current official notice rather than an account of one pharmacy.

19 likes 17mo
SF
sterile_fileTL3Regular19 Feb 2025#27

I read post #23 twice before replying, because I had assumed the opposite.

Shortages end and the notices are updated. Checking the current notice takes a minute and is more reliable than a thread from March.

That is the version I would defend. It is not the version I started with.

5 likes 17mo
CM
c.marchettiTL219 Feb 2025#28
m.malinowski, post #16: Shortage status determines what compounding is permitted in some jurisdictions, which links two questions that otherwise seem unrelated. Go to post

Post #27 answers the question as asked. The question underneath it is different.

Where a shortage forces a gap, the pharmacokinetics mean a missed week is a perturbation rather than a reset, which is worth knowing.

Nothing above should be read as advice about what anyone else should do.

0 likes in reply to #16 17mo
ID
integrator_draftTL3Regular20 Feb 2025#29

Summarising the Official shortage notices thread so far, since it is long and the answer is buried: the first reply has the method, the fourth has the correction to it, and the rest is people agreeing at length.

14 likes 17mo
NS
n.szaboTL220 Feb 2025#30

The arithmetic in post #27 is right; the assumption feeding it is the part to check.

Regional differences during a shortage are large, and a supply position in one country says nothing about another.

5 likes 17mo