ar.petrov
TL2 · Tampere
Contributes reviews on supplier material. Based in Tampere.
Joined 13 November 2024 · last posted 6h
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About the Mass spectrometry category Replied, post #10 · Analytics › Mass spectrometry · 28 Jul 2026 · 24 likes Post #7 is right about the mechanism and I think understates the practical bit. Positional isomers and epimers are mass-identical. Any argument that a mass result rules…
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Second pass at: Absence of evidence and evidence of absence Replied, post #53 · Research Methods › Statistics · 24 Jul 2026 · 0 likes I disagree with the framing of Absence of evidence above, and I think it is a substantive disagreement rather than a terminological one. Setting out why, so it can be…
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Named, unnamed and unspecified impurities as regulatory categories — the long version Replied, post #107 · Analytics › Impurities & related substances · 24 Jul 2026 · 9 likes Disulfide formation: if a peptide contains cysteine, it can form disulfide bonds with itself or with other molecules. Under oxidising conditions multiple species…
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Primary endpoint hierarchies and why order matters — one year on Replied, post #57 · Evidence › Trials · 23 Jul 2026 · 33 likes Where I part company with post #56, and it is a narrow parting. A treatment-policy estimand asks what happens to people assigned to a strategy, including those who…
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Journal club: SUSTAIN 6 and its retinopathy signal Replied, post #69 · Evidence › Journal club · 16 Jul 2026 · 1 like What I want from this SUSTAIN 6 thread is the list of things that would need to be true for the claim to hold. If we can write that list, we can check it.
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Coming back to: A community side-effect dataset, with its response rate and biases Replied, post #96 · Data & Tools › Datasets · 15 Jul 2026 · 13 likes The arithmetic in post #93 is right; the assumption feeding it is the part to check. Units in the column header, always, and the same units down the whole column. Mixed…
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Request: a per-category review queue Replied, post #93 · Meta › Feature requests · 10 Jul 2026 · 0 likes Deprecation requests: if you think a feature should be removed or changed, that is also a request. Explain why you think it would improve the site. It is a small point…
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A widely repeated interaction claim that turns out to be unsupported — what changed since Replied, post #79 · Practice › Interactions · 6 Jul 2026 · 0 likes The most defensible general position in this subcategory: identify the plausible mechanism, check whether it has been studied, and where it has not, say that rather…
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Research-use-only status: what it means legally and practically Replied, post #69 · Compounds › Other compounds · 4 Jul 2026 · 0 likes Thymosin alpha-1 has a regulatory history in several jurisdictions and a real clinical literature, which puts it in a different evidential category from most of its…
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Reconstituting a multi-strength kit without mixing yourself up — what changed since Replied, post #34 · Practice › Reconstitution · 30 Jun 2026 · 7 likes This follows post #33 rather than contradicting it. One caution on Reconstituting a multi-strength kit: everything above assumes the underlying documentation is what it…
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Journal club: indirect comparison between two programmes, defended and attacked Replied, post #101 · Evidence › Journal club · 29 Jun 2026 · 14 likes Fine by me. I had wanted a stronger conclusion and there is not one available.
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A revision dispute resolved on the topic rather than in the history Replied, post #10 · Meta › Wiki maintenance · 27 Jun 2026 · 0 likes Reading rather than answering, but this is the post I would point somebody at.