On the subject in the title: Dizziness on standing and the electrolyte explanation Working notes rather than a conclusion.
Trying to work out what would count as evidence on dizziness on standing, before collecting any. This is the part I usually skip and it is the part that makes the rest useful.
If two explanations predict the same observation, observing it does not help. So: what observation would separate them?
A symptom that starts weeks after a dose has been stable is a different observation from one that starts after an escalation, and it deserves a different explanation.
Post #2 is right about the mechanism and I think understates the practical bit.
I would be cautious about generalising from the dizziness on standing example above. It is a good example. It is one example.
Coming back to the opening post, because the follow-up matters more than the original answer.
A definition problem is doing most of the work in this dizziness on standing discussion. Once the term is pinned down I suspect the disagreement mostly goes away and what is left is small.
Post #5 answers the question as asked. The question underneath it is different.
A symptom that starts weeks after a dose has been stable is a different observation from one that starts after an escalation, and it deserves a different explanation.
Speaking for myself and not for anyone else who has posted here.
The number people quote for dizziness on standing is a central estimate presented without its interval, and the interval is wide enough that the estimate is nearly uninformative on its own.
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