n.bridgewater
TL2 Member · Leiden, NL
Practical questions, practical answers. Not interested in speculation without a source.
Joined 9 January 2025 · last posted 2d · groups: regional-na
91Posts here
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1Solutions
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Why a glucagon receptor agonist in a weight-loss compound is not a contradiction Replied, post #48 · Compounds › Retatrutide · 26 Jul 2026 · 32 likes Bookmarking this. I will come back when I have something worth adding.
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eGFR fluctuation and the creatinine denominator problem — the long version Replied, post #13 · Clinical › Bloodwork · 18 Jul 2026 · 6 likes If someone has run egfr fluctuation properly I would rather read that than my own reconstruction of it. Posting mine only because the thread has gone quiet.
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Selection into a registry and what it does to the estimate — a second dataset Replied, post #21 · Evidence › Study critique · 17 Jul 2026 · 11 likes Taking post #18 at face value and following it one step further. Per-protocol and intention-to-treat analyses answer different questions and neither is the honest one…
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Follow-up: Sleep quality changes during weight loss Replied, post #72 · Wellbeing › Sleep · 17 Jul 2026 · 11 likes Appetite suppression and nighttime eating: if nighttime eating was a pattern, appetite suppression changes that pattern. Sleep can worsen if nighttime waking is…
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Coming back to: Where the four-week escalation interval comes from, and what it is not Replied, post #28 · Practice › Dosing & titration · 15 Jul 2026 · 30 likes Post #25 describes the usual case. This is about the unusual one. I read the earlier replies on four-week escalation interval twice before writing this, because I had…
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Request: a per-category review queue Replied, post #104 · Meta › Feature requests · 15 Jul 2026 · 9 likes That would also make review dates far more meaningful. A document cited by forty topics and a document cited by none need very different amounts of attention. I am…
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[2026 update] Regional warehouse stock versus direct despatch Replied, post #130 · Sourcing › Logistics · 11 Jul 2026 · 21 likes Import restrictions by jurisdiction: what is legal to import for personal use varies enormously by country. Some jurisdictions are quite permissive; others are not.…
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Electrolyte supplements: which ones do anything Replied, post #51 · Nutrition & Training › Hydration & electrolytes · 9 Jul 2026 · 22 likes On post #48 — agreed on the reasoning, with one qualification. The bit of electrolyte supplements that nobody enjoys is that the answer changes depending on what you…
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I joined for one answer and stayed for a year — what changed my mind Replied, post #64 · Start Here › Welcome · 6 Jul 2026 · 7 likes The category structure looks heavier than it is. There are twenty top-level categories and you will use three of them. Find those three, mute the rest for a month, and…
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Why fasting instructions for oral semaglutide are not optional advice Replied, post #70 · Compounds › Oral incretins · 2 Jul 2026 · 6 likes Oral versus injectable exposure: comparing a 14 mg oral dose with a 0.5 mg injectable dose is comparing apples to a different fruit. The oral bioavailability is low…
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Coming back to: Telehealth prescribing models in the US Replied, post #2 · Regional › North America · 30 Jun 2026 · 13 likes Reporting rather than recommending, on Telehealth prescribing models. What happened is above. Whether it should have is a different question and not one I am qualified…
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Pooling trials with different estimands Replied, post #50 · Evidence › Meta-analyses · 26 Jun 2026 · 0 likes Study quality and weighting: some meta-analyses weight all studies equally; others weight by study size or study quality. The choice affects the result and should be…