Dose numbers across compounds are not on the same scale — setting out what I have, and where I think it stops being reliable.
I would like to disagree carefully with the settled view on dose numbers across compounds, and I would like to be argued out of it if the disagreement is bad.
The disagreement is about one step, not about the conclusion. If the step holds I withdraw it entirely.
A missed dose in a weekly schedule is not a trough to chase. With a week-long half-life you are perturbing a slowly moving average, and the labelling for licensed products in this class says take it if the next dose is far enough away and skip it otherwise.
I would put a moderate confidence on that and no more.
Where I part company with the opening post, and it is a narrow parting.
Escalating before steady state means you are judging a dose you have not yet fully experienced. That is the whole argument against compressing the schedule and it is a good one.
I checked the source rather than the summary, and they differ.
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