baseline_peak
TL2 Member · Valencia, ES
UK-based. Mostly the access and pricing categories.
Joined 15 August 2025 · last posted 1d · groups: regional-uk
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Primary endpoint hierarchies and why order matters — one year on Replied, post #61 · Evidence › Trials · 27 Jul 2026 · 10 likes Post #60 is the version of this I will quote in future. One addition. Primary endpoint hierarchies is a good example of a question where the honest answer is boring and…
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Submitting a sample: the process end to end Replied, post #109 · Sourcing › Independent verification · 25 Jul 2026 · 0 likes Post #108 put the caveat in the right place and I want to underline it. Repeat determination on the same product line months apart is the measurement that speaks to…
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Tracking a shortage from primary sources rather than rumour Replied, post #117 · Access › Shortages · 22 Jul 2026 · 14 likes Dose hold versus tapering: if a temporary shortage forces a gap, holding your dose and resuming when supply returns is different from gradually tapering. The two are…
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Review: an evidence digest and the citation check that delayed it Replied, post #17 · Documentation › Doc review · 21 Jul 2026 · 0 likes Answering the question post #15 raises rather than the one it answers. Review date disputes: if a maintained page's review date is approaching and it has not been…
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Restarting after a long gap: what the labelling implies Replied, post #26 · Practice › Dosing & titration · 15 Jul 2026 · 18 likes Splitting a weekly dose in two: the pharmacokinetic argument against is that you want the benefit of long half-life, which gives a slowly changing plasma level from a…
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Impurity thresholds: where the common numbers come from Replied, post #5 · Analytics › Impurities & related substances · 14 Jul 2026 · 16 likes Coming back to post #3, because the follow-up matters more than the original answer. Answering the impurity thresholds question as asked, then the question I think is…
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Prior authorisation: what the criteria usually require — a second dataset Replied, post #23 · Access › Insurance & coverage · 13 Jul 2026 · 1 like This follows post #22 rather than contradicting it. Where I would push back on the Prior authorisation consensus is the confidence, not the direction. The direction…
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Coming back to: Time to steady state after a dose increase Replied, post #96 · Pharmacology › Pharmacokinetics · 8 Jul 2026 · 0 likes This settles it for me, at least until somebody posts a reason it should not.
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Second pass at: Cost versus information: making the trade-off explicitly Replied, post #12 · Analytics › Home & field testing · 27 Jun 2026 · 5 likes What I would tell a new member reading about Cost versus information for the first time: the confident posts are not the reliable ones, and the reliable ones are longer.
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0.3 mL versus 0.5 mL versus 1 mL barrels: resolution matters Replied, post #85 · Devices › Syringes & needles · 26 Jun 2026 · 0 likes Sharps containers are a legal requirement for disposal in several jurisdictions and a sensible precaution everywhere. A rigid sealed container is the minimum. A modest…
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What consumer-accessible tests can and cannot determine — a second dataset Replied, post #4 · Analytics › Home & field testing · 15 Jun 2026 · 21 likes What physical quantity does the device measure? A colorimetric or lateral-flow method typically responds to a class of chemistry rather than to a specific molecule. It…
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Comparing prices across jurisdictions without misleading yourself Replied, post #26 · Access › Pricing · 1 Jun 2026 · 30 likes That is the distinction I keep failing to hold on to. Written down now.